主持和参与的主要研究课题:

1.  国家自然科学基金委员会创新研究群体项目，深海界面过程和化能生态系统，2023.1-2027.12。

2.  中科院“一带一路”国际科学组织联盟联合研究，“珊瑚大三角”海洋微塑料污染对生态安全的影响评估和应对，2023.1-2025.12。

3.  山东省“十四五”重大项目，微生物介导的地化循环过程及关键生物类群生态功能，2022.5-2025.4。

4.  国家自然科学基金委重大研究计划培育项目，深海冷泉奇古菌和浮霉菌在生长和驱动氮元素循环过程中的互作机制研究，2021.1-2023.12。

5.  中国科学院先导专项，板块俯冲体系下的特殊生命过程，2019.1-2023.12。

6.  科技部重点研发计划，深海冷泉生物多样性、环境适应性与应用潜力评估，2018.9-2021.12。

代表性研究论文:

1.  Ruining Cai, Wanying He, Jing Zhang, Rui Liu, Ziyu Yin, Xin Zhang, Chaomin Sun*. Blue light promotes zero-valent sulfur production in a deep-sea bacterium. The EMBO Journal, 2023, e112514. DOI: 10.15252/embj.2022112514.

2.  Rikuan Zheng, Ruining Cai, Chong Wang, Rui Liu, Chaomin Sun^*. Characterization of the first cultured representative of “Candidatus Thermofonsia” Clade 2 within Chloroflexi reveals its phototrophic lifestyle. mBio, 2022, 13(2): e00287-22. Doi: 10.1128/mbio.00287-22.

3.  Ruining Cai, Wanying He, Rui Liu, Jing Zhang, Xin Zhang, Chaomin Sun^*. Deep-sea in situ insights into the formation of zero-valent sulfur driven by a bacterial thiosulfate oxidation pathway. mBio, 2022, 13(4). Doi: 10.1128/mbio.00143-22.

4.  Rongrong Gao, Rui Liu, Chaomin Sun^*. A marine fungus Alternaria alternata FB1 efficiently degrades polyethylene. Journal of Hazardous Materials, 2022, 431: 128617. Doi: 10.1016/j.jhazmat.2022.128617.

5.  Rikuan Zheng, Rui Liu, Yeqi Shan, Ruining Cai, Ge Liu, Chaomin Sun^*. Characterization of the first cultured free-living representative of Candidatus Izemoplasma uncovers its unique biology. The ISME Journal, 2021, 15(9):2676-2691. doi: 10.1038/s41396-021-00961-7.

6.  Ge Liu, Rui Liu, Yeqi Shan, Chaomin Sun^*. Marine bacterial exopolysaccharide EPS11 inhibits migration and invasion of liver cancer cells by directly targeting collagen I. Journal of Biological Chemistry, 2021, 297(4):101133. doi: https://doi.org/10.1016/j.jbc.2021.101133.

7.  Rikuan Zheng, Ruining Cai, Rui Liu, Ge Liu, Chaomin Sun^*. Maribellus comscasis sp. nov., a novel deep-sea Bacteroidetes bacterium, possessing a prominent capability of degrading cellulose. Environmental Microbiology, 2021, 23(8):4561-4575. Doi: 10.1111/1462-2920.15650.

8.  Ge Liu, Yeqi Shan, Rikuan Zheng, Rui Liu, Chaomin Sun^*. Growth promotion of a deep-sea bacterium by sensing infrared light through a bacteriophytochrome photoreceptor. Environmental Microbiology, 2021, 23(8):4466-4477. Doi: 10.1111/1462-2920.15639.

9.  Rongrong Gao, Chaomin Sun*. A marine bacterial community capable of degrading poly(ethylene terephthalate) and polyethylene. Journal of Hazardous Materials, 2021, 416, 125928. doi: 10.1016/j.jhazmat.2021.125928.

10. Ruining Cai, Jing Zhang, Rui Liu, Chaomin Sun^*. Metagenomic insights into the metabolic and ecological functions of abundant deep-sea hydrothermal vent DPANN archaea. Applied and Environmental Microbiology, 2021, 87(9):e03009-20. doi: 10.1128/AEM.03009-20.

11. Rikuan Zheng, Shimei Wu, Chaomin Sun^*. MerF is a novel regulator of deep-sea Pseudomonas stutzeri flagellum biogenesis and motility. Environmental Microbiology, 2021, 23(1):110-125. doi: 10.1111/1462-2920.15275.

12. Ning Ma, Zhongli Sha, Chaomin Sun*. Formation of cadmium sulfide nanoparticles mediates cadmium resistance and light utilization of the deep-sea bacterium Idiomarina sp. OT37-5b. Environmental Microbiology, 2021, 23(2):934-948. doi: 10.1111/1462-2920.15205.

13. Ning Ma, Ruining Cai, Chaomin Sun*. Threonine dehydratase enhances bacterial cadmium resistance via driving cysteine desulfuration and biomineralization of cadmium sulfide nanocrystals. Journal of Hazardous Materials, 2021, 417:126102. doi: 10.1016/j.jhazmat.2021.126102.

14. Zuodong Wu, Rikuan Zheng, Ge Liu, Rui Liu, Shimei Wu^*, Chaomin Sun ^*. Calcium protects bacteria against    cadmium stress via reducing nitric oxide production and increasing iron acquisition. Environmental Microbiology, 2021, 23(7):3541-3553. doi: 10.1111/1462-2920.15237.

15. Shengnan Zhou, Ge Liu, Rikuan Zheng, Chaomin Sun^*, Shimei Wu^*. Structural and functional insights of iturin W, a novel lipopeptide produced by the deep-sea bacterium Bacillus sp. wsm-1. Applied and Environmental Microbiology, 2020, 86(21):e01597-20 DOI: 10.1128/AEM.01597-20.

16. Rui Liu, Rikuan Zheng, Ge Liu, Chaomin Sun*. The cyclic lipopeptides suppress the motility of Vibrio alginolyticus via targeting the Na⁺-driven flagellar motor component MotX. Environmental Microbiology, 2020, 22(10): 4424-4437. DOI: 10.1111/1462-2920.15144.

17. Jing Zhang, Rui Liu, Shichuan Xi, Ruining Cai, Xin Zhang, Chaomin Sun*. A novel bacterial thiosulfate oxidation pathway provides a new clue about the formation of zero-valent sulfur in deep sea. The ISME Journal, 2020, 14(9):2261-2274. DOI: 10.1038/s41396-020-0684-5.

18. Ge Liu, Shan Kuang, Ruobing Cao, Ju Wang, Quancai Peng, Chaomin Sun*. Sorafenib kills Huh7.5 liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via ATP-AMPK-mTOR-SREBP1 signaling pathway. FASEB J. 2019, 33(9), doi: 10.1096/fj.201802619RR.

19. Ge Liu, Kai Wang, Shan Kuang, Ruobing Cao, Li Bao, Rui Liu, Hongwei Liu*, Chaomin Sun*. The natural compound GL22, isolated from Ganoderma mushrooms, suppresses tumor growth by altering lipid metabolism and triggering cell death. Cell Death and Disease, 2018, 9(689), doi: 10.1038/s41419-018-0731-6.

20. Linlin Zhang, Chaomin Sun*. Fengycins, cyclic lipopeptides from marine Bacillus subtilisstrains, kill the plant-pathogenic fungus Magnaporthe grisea by inducing reactive oxygen species production and chromatin condensation. Applied and Environmental Microbiology, 2018, 84(18): e00445-18. doi: 10.1128/AEM.00445-18.  

21. Pengyuan Xiu, Rui Liu, Dechao Zhang*, Chaomin Sun*. Pumilacidin-like lipopeptides derived from marine bacterium Bacillus sp. suppress the motility of Vibrio alginolyticus. Applied and Environmental Microbiology, 2017, 83(12). doi: 10.1128/AEM.00450-17.

22. Chaomin Sun^#，Jordi Querol-Audi，Stefanie A. Mortimer，Ernesto Arias-Palomo，Jennifer A. Doudna，Eva Nogales，Jamie H. D. Cate. Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation. Nucleic Acids Research, 2013, 41(15): 7512-7521, doi: 10.1093/nar/gkt510.

23. Chaomin Sun^#, Todorovic A^#, Querol-Audí J, Bai Y, Villa N, Snyder M, Ashchyan J, Lewis CS, Hartland A, Gradia S, Fraser C, Doudna J, Nogales E, Cate J. Functional reconstitution of human translation initiation factor eIF3. PNAS, 2011 108(51): 20473-20478.

24. Chaomin Sun^#, Meixian Zhou, Yun Li, Hua Xiang. Molecular characterization of the minimal replicon and the unidirectional theta replication of pSCM201 in extremely halophilic archaea. Journal of Bacteriology, 2006, 188(23): 8136-8144.

25. Chaomin Sun^#, Yun Li^#, Shuangshuang Mei, Qiuhe Lu, Ligang Zhou，Hua Xiang. A single gene directs both production and immunity of halocin C8 in a haloarchaeal strain AS7092. Molecular Microbiology, 2005, 57 (2), 537–549.