邢丽丽----中国科学院海洋研究所

生物与医药

邢丽丽，女，副研究员，中国海洋湖沼学会棘皮动物分会副秘书长，牛津大学、杜克大学访问学者。主要从事棘皮动物体色调控机制与基因编辑育种等方面研究，系统揭示了刺参体色多样性形成的分子调控路径和生态适应机制，率先创建了刺参基因编辑育种技术体系，实现了顺式调控元件高效编辑，作为第三完成人培育了紫刺参新品系。相关研究成果以第一作者在Philosophical Transactions B、Food Chemistry等期刊发表SCI论文12篇、通讯作SCI论文2篇，授权第一发明人专利4项，参编专著3部，主持国家自然科学基金、国家重点研发计划子课题等项目6项，入选山东省青年科技人才托举工程，获海洋科学技术奖一等奖、青岛市青年科技奖、中国科学院院长优秀奖等荣誉，担任Frontiers in Marine Science、Frontiers in Physiology编委，中国科学院大学本科招生山东招生组专家，中国科学院海洋研究所研究生班主任等。

一、研究领域

主要聚焦于棘皮动物体色分化的分子遗传机制与生态适应性演化，系统揭示刺参等海洋无脊椎动物的色素形成、发育调控及环境适应间的内在联系。应用基因组学与基因编辑等手段，推动关键性状分子的遗传解析与优良品系分子育种技术创新。

二、招生专业及方向

海洋生态学（生物资源生态学）；生物与医药

三、研究室及联系方式

海洋生态与环境科学重点实验室

邮箱：lilixing@qdio.ac.cn

电话：0532-82898645

四、承担的主要科研项目

1. 国家自然科学基金, 刺参色素沉积关键顺式调控元件鉴定与调控机制解析, 主持

2. 国家重点研发计划子课题，海洋牧场智能管控与少人化精准协同作业应用示范，主持

3. 山东省自然科学基金面上项目，刺参体色多样性形成的生态适应性机制，主持

4. 山东省自然科学基金青年项目，刺参色素沉积作用特征及调控元件解析，，主持

5. 中国博士后科学基金面上项目，刺参体色关键基因及关键顺式调控元件的定位与解析，主持

6. 青岛市博士后研究人员应用研究项目资助，刺参体色形成调控路径解析与育种应用，主持

五、研究成果及奖励

山东省青年科技人才托举工程；2024

青岛市青年科技奖; 2024

海洋科学技术一等奖; 2022

中国科学院院长优秀奖; 2019

中国科学院海洋研究所“优秀博士后”出站奖励, 2021

北京市优秀毕业生; 2019

中国科学院大学优秀毕业生; 2019

国家奖学金; 2017

六、代表性论文及著作

(1) Gary Wessel#; Lili Xing#; Nathalie Oulhen. More than a color, how pigment influences colorblind microbes. Philosophical Transactions of the Royal Society B-Biological Sciences. 2024. 379: 20230077. https://doi.org/10.1098/rstb.2023.0077.

(2) Lili Xing; Lina Sun; Shilin Liu; Libin Zhang; Hongsheng Yang; Comparative metabolomic analysis of the body wall from four varieties of the sea cucumber Apostichopus japonicus. Food Chemistry, 2021, 352: 129339.

(3) Lili Xing; Lina Sun; Shilin Liu; Xaioni Li; Libin Zhang; Hongsheng Yang; Transcriptome analysis provides insights into the mechanism of albinism during different pigmentation stages of the albino sea cucumber Apostichopus japonicus. Aquaculture, 2018, 486: 148-160.

(4) Lili Xing; Shilin Liu; Libin Zhang; Hongsheng Yang; Lina Sun. Landscape and dynamics of accessible chromatin during pigmentation process in green, white and purple sea cucumber Apostichopus japonicus. Aquaculture Reports. 2022, 23:101040.

(5) Lili Xing, Lingyu Wang, Shilin Liu, Lina Sun, Gary M Wessel, Hongsheng Yang. Single-Cell Transcriptome and Pigment Biochemistry Analysis Reveals the Potential for the High Nutritional and Medicinal Value of Purple Sea Cucumbers. International Journal of Molecular Sciences. 2023; 24(15):12213.

(6) Lili Xing; Shilin Liu; Libin Zhang; Hongsheng Yang; Lina Sun, MITF contributes to the body color differentiation of sea cucumbers Apostichopus japonicus through expression differences and regulation of downstream genes. Biology 2022, 12: 1.

(7) Lili Xing; Lingyu Wang; Femke Roos; Michelle Lee; Gregory Wray. CRISPR/Cas9-mediated disruption of Endo16 cis-regulatory elements in sea urchin embryos. Fishes, 2023, 8: 118.

(8) Lili Xing; Lina Sun; Shilin Liu; Libin Zhang; Jingchun Sun; Hongsheng Yang; Metabolomic analysis of white, green and purple morphs of sea cucumber Apostichopus japonicus during body color pigmentation process. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2021, 39: 100827.

(9) Bohong Liu; Lili Xing*; Shilin Liu; Lina Sun; Fang Su; Wei Cui; Chunxi Jiang. Transcriptome analysis of purple and green Apostichopus japonicus reared under different breeding environments. Frontiers in Marine Science. 2024, https://doi.org/10.3389/fmars.2024.1334761.

(10) Bohong Liu; Shilin Liu; Lina Sun; Lili Xing*. Revealing the adaptation mechanism of different color morphs of sea cucumber Apostichopus japonicus to light intensities from the perspective of metabolomics. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2024, 52: 101346.

(11) Lili Xing; Lina Sun; Shilin Liu; Xiaoni Li; Libin Zhang; Hongsheng Yang; De Novo assembly and comparative transcriptome analyses of purple and green morphs of Apostichopus japonicus during body wall pigmentation process, Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2018, 28: 151-161.

(12) Lili Xing; Lina Sun; Shilin Liu; Zixuan Wan; Xiaoni Li; Ting Miao; Libin Zhang; Yucen Bai; Hongsheng Yang; Growth, histology, ultrastructure and expression of MITF and astacin in the pigmentation stages of green, white and purple morphs of the sea cucumber, Apostichopus japonicus. Aquaculture Research, 2018, 49(1): 177-187.

(13) Lili Xing; Lina Sun; Shilin Liu; Xiaoni Li; Libin Zhang; Hongsheng Yang; IBT-based quantitative proteomics identifies potential regulatory proteins involved in pigmentation of purple sea cucumber, Apostichopus japonicus. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2017, 23: 17-26.

(14) Lili Xing; Lina Sun; Shilin Liu; Xiaoni Li; Ting Miao; Libin Zhang; Hongsheng Yang; Comparison of pigment composition and melanin content among white, light-green, dark-green, and purple morphs of sea cucumber, Apostichopus japonicus. Acta Oceanologica Sinica, 2017, 36(12): 45-51.