邢丽丽，女，副研究员，中国科学院大学硕士生导师，中国海洋湖沼学会棘皮动物分会副秘书长，牛津大学、杜克大学访问学者，青岛市青年科学家协会女科技工作者专委会副主任委员。主要从事棘皮动物体色调控机制与基因编辑育种、生物时间离散性等方面研究，系统揭示了刺参体色多样性形成的分子调控路径和生态适应机制，率先创建了刺参基因编辑育种技术体系，实现了顺式调控元件高效编辑，作为第三完成人培育了紫刺参新品系。相关研究成果以第一/通讯作者在Philosophical Transactions B、Food Chemistry等期刊发表SCI论文15篇，授权第一发明人专利4项，参编专著4部，主持国家自然科学基金、国家重点研发计划子课题等项目7项，入选山东省青年科技人才托举工程，获海洋科学技术奖一等奖、青岛市青年科技奖、中国科学院院长优秀奖等荣誉，担任Frontiers in Marine Science、Frontiers in Physiology编委，中国科学院大学本科招生山东招生组专家，中国科学院海洋研究所研究生班主任等。

一、研究领域  

围绕棘皮动物重要表型的形成、演化与精准改良，重点开展以下研究：

（1）棘皮动物体色形成、多态性维持及生态适应机制；

（2）海洋无脊椎动物发育过程的时空调控与生物时间机制；

（3）棘皮动物精准基因编辑与重要性状分子设计育种。

二、招生专业及方向

海洋生态学（生物资源生态学）；生物与医药

三、研究室及联系方式       

海洋生态与环境科学重点实验室

邮箱：lilixing@qdio.ac.cn

电话：0532-82898645

四、承担的主要科研项目

1. 国家自然科学基金委员会青年科学基金项目, 刺参色素沉积关键顺式调控元件鉴定与调控机制解析，主持

2. 国家重点研发计划子课题，海洋牧场智能管控与少人化精准协同作业应用示范，主持

3. 山东省自然科学基金面上项目，刺参体色多样性形成的生态适应性机制，主持

4. 山东省自然科学基金青年项目，刺参色素沉积作用特征及调控元件解析，主持

5. 中国博士后科学基金面上项目，刺参体色关键基因及关键顺式调控元件的定位与解析，主持

6. 威海市2025年渔业科技创新计划，海胆种质创新与大规格苗种保育技术应用，主持

7. 青岛市博士后研究人员应用研究项目资助，刺参体色形成调控路径解析与育种应用，主持

五、研究成果及奖励         

山东省青年科技人才托举工程，2024

青岛市青年科技奖，2024

海洋科学技术一等奖，2022

中国科学院院长优秀奖，2019

中国科学院海洋研究所“优秀博士后”出站奖励，2021

北京市优秀毕业生，2019

中国科学院大学优秀毕业生，2019

国家奖学金，2017

六、代表性论文及著作

论文

(1) Lili Xing*, Junqi Yan, Shilin Liu, Bohong Liu, Libin Zhang*. Integrated analysis of nutrient composition and metabolomics reveals the biochemical basis of color-associated quality in a newly bred purple sea cucumber (Apostichopus japonicus). Food Chemistry, 2026, https://doi.org/10.1016/j.foodchem.2026.148809.

(2) Bohong Liu; Shilin Liu; Lina Sun; Lili Xing*. Revealing the adaptation mechanism of different color morphs of sea cucumber Apostichopus japonicus to light intensities from the perspective of metabolomics. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2024, 52: 101346.

(3) Gary Wessel#; Lili Xing#; Nathalie Oulhen. More than a color, how pigment influences colorblind microbes. Philosophical Transactions of the Royal Society B-Biological Sciences. 2024. 379: 20230077. https://doi.org/10.1098/rstb.2023.0077.

(4) Bohong Liu; Lili Xing*; Shilin Liu; Lina Sun; Fang Su; Wei Cui; Chunxi Jiang. Transcriptome analysis of purple and green Apostichopus japonicus reared under different breeding environments. Frontiers in Marine Science. 2024, https://doi.org/10.3389/fmars.2024.1334761.

(5) Lili Xing, Lingyu Wang, Shilin Liu, Lina Sun*, Gary M Wessel*, Hongsheng Yang. Single-Cell Transcriptome and Pigment Biochemistry Analysis Reveals the Potential for the High Nutritional and Medicinal Value of Purple Sea Cucumbers. International Journal of Molecular Sciences. 2023; 24(15):12213. 

(6) Lili Xing; Lingyu Wang; Femke Roos; Michelle Lee; Gregory Wray*. CRISPR/Cas9-mediated disruption of Endo16 cis-regulatory elements in sea urchin embryos. Fishes, 2023, 8: 118.

(7) Lili Xing; Shilin Liu; Libin Zhang; Hongsheng Yang; Lina Sun* Landscape and dynamics of accessible chromatin during pigmentation process in green, white and purple sea cucumber Apostichopus japonicus. Aquaculture Reports. 2022, 23:101040.

(8) Lili Xing; Shilin Liu; Libin Zhang; Hongsheng Yang; Lina Sun, MITF contributes to the body color differentiation of sea cucumbers Apostichopus japonicus through expression differences and regulation of downstream genes. Biology 2022, 12: 1.

(9) Lili Xing; Lina Sun; Shilin Liu*; Libin Zhang; Hongsheng Yang; Comparative metabolomic analysis of the body wall from four varieties of the sea cucumber Apostichopus japonicus. Food Chemistry, 2021, 352: 129339.

(10) Lili Xing; Lina Sun*; Shilin Liu; Libin Zhang; Jingchun Sun; Hongsheng Yang; Metabolomic analysis of white, green and purple morphs of sea cucumber Apostichopus japonicus during body color pigmentation process. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2021, 39: 100827.

(11) Lili Xing; Lina Sun*; Shilin Liu; Xaioni Li; Libin Zhang; Hongsheng Yang*; Transcriptome analysis provides insights into the mechanism of albinism during different pigmentation stages of the albino sea cucumber Apostichopus japonicus. Aquaculture, 2018, 486: 148-160.

(12) Lili Xing; Lina Sun*; Shilin Liu; Xiaoni Li; Libin Zhang; Hongsheng Yang*; De Novo assembly and comparative transcriptome analyses of purple and green morphs of Apostichopus japonicus during body wall pigmentation process, Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2018, 28: 151-161.

(13) Lili Xing; Lina Sun*; Shilin Liu; Zixuan Wan; Xiaoni Li; Ting Miao; Libin Zhang; Yucen Bai; Hongsheng Yang*; Growth, histology, ultrastructure and expression of MITF and astacin in the pigmentation stages of green, white and purple morphs of the sea cucumber, Apostichopus japonicus. Aquaculture Research, 2018, 49(1): 177-187.

(14) Lili Xing; Lina Sun*; Shilin Liu; Xiaoni Li; Libin Zhang; Hongsheng Yang*; IBT-based quantitative proteomics identifies potential regulatory proteins involved in pigmentation of purple sea cucumber, Apostichopus japonicus. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2017, 23: 17-26.

(15) Lili Xing; Lina Sun*; Shilin Liu; Xiaoni Li; Ting Miao; Libin Zhang; Hongsheng Yang*; Comparison of pigment composition and melanin content among white, light-green, dark-green, and purple morphs of sea cucumber, Apostichopus japonicus. Acta Oceanologica Sinica, 2017, 36(12): 45-51.

专著

1. 《增殖型海洋牧场技术模式》，2021年，中国农业出版社

2. 《现代渔业科技创新发展现状与展望》，2022年，科学出版社

3. 《The World of Sea Cucumbers: Challenges, Advances, and Innovations》，2023年，Academic Press

4. 《现代海洋牧场探索与实践》，2025年，科学出版社