一、研究领域
1.甲壳动物重要经济性状遗传解析：利用生物信息学、统计遗传学、分子生物学技术，鉴定调控虾类生长、抗性和品质性状的关键基因，解析性状形成的遗传机理。
2.甲壳动物分子育种：研发并应用全基因组选择育种、分子模块设计等精准育种技术，培育高产、高抗、优质的虾类新品种。
二、招生专业及方向
1.海洋生物学，遗传学与遗传工程
2.水产养殖，养殖遗传学与育种生物技术
3.生物与医药，海洋生物工程
三、研究室及联系方式
实验海洋生物学重点实验室，邮箱：yuyang@qdio.ac.cn 电话：0532-82898568
四、承担的主要科研项目
1、国家重点研发计划项目课题，2022YFD2400203，抗偷死综合征凡纳滨对虾新品种选育-课题2：重要经济性状的精准育种技术研发-子课题：凡纳滨对虾品质性状的基因组选择技术体系构建，2022.11-2026.12，40万，在研，子课题负责人。
2、山东省重点研发项目，水产种质资源挖掘与精准鉴定，2022.01-2024.12，49万，在研，子课题负责人。
3、国家重点研发计划项目,重要水产养殖生物抗病和抗逆性状的遗传基础与调控机制-课题三：虾蟹耐低盐低氧与抗病性状的遗传关联机制（2018YFD0900303），2018/12-2022/12，75万，已结题，子课题负责人。
4、山东省农业良种工程项目优质高抗对虾突破性新品种选育，子课题：对虾分子育种技术研究（2019LZGC014，），2019.7-2022.7，105万，已结题，子课题负责人。
5、国家自然科学基金青年基金项目，对虾WSSV抗性相关SNP鉴定及其抗性机理研究（31502161），2016.01-2018.12,24万，已结题，主持。
6、重要横向课题，对虾现代育种技术研发与应用，2019.08-2024.08， 200万，在研，课题负责人。
五、研究成果及奖励
以第一、共同第一和通讯作者发表Nature communication、Frontiers in genetics、Aquaculture等SCI文章25篇，授权国家发明专利18项，公开国家发明专利14项，授权美国国家发明专利1项，作为骨干完成了凡纳滨对虾“科海1号”、“广泰1号”、“渤海1号”和脊尾白虾“科苏红1号”新品种的选育和推广，研究成果获得第十一届大北农科技奖水产科学奖一等奖和山东省科技进步一等奖等。
六、代表性论文及著作
1. Xiaojun Zhang#, Jianbo Yuan#, Yamin Sun#, Shihao Li#, Yi Gao#, Yang Yu#, Chengzhang Liu, Quanchao Wang, Xinjia Lv, Xiaoxi Zhang, Ka Yan Ma, Xiaobo Wang, Wenchao Lin, Long Wang, Xueli Zhu, Chengsong Zhang, Jiquan Zhang, Songjun Jin, Kuijie Yu, Jie Kong, Peng Xu, Jack Chen, Hongbin Zhang, Patrick Sorgeloos, Amir Sagi, Acacia Alcivar-Warren, Zhanjiang Liu, Lei Wang, Jue Ruan, Ka Hou Chu*, Bin Liu*, Fuhua Li*, Jianhai Xiang*, Penaeid shrimp genome provides insights into benthic adaptation and frequent molting, Nature Communications, 2019, 10:356.
2. Yang Yu#, Quanchao Wang#, Qian Zhang, Zheng Luo, Yue Wang, Xiaojun Zhang, Hao Huang, Jianhai Xiang, Fuhua Li*. Genome Scan for Genomic Regions and Genes Associated with Growth Trait in Pacific White Shrimp Litopeneaus vannamei. Marine Biotechnology, 2019, 21(3), 374-383.
3. Yang Yu#, Jingwen Liu#, Fuhua Li, Xiaojun Zhang, Chengsong Zhang，Jianhai Xiang. Gene set based association analyses for the WSSV resistance of Pacific white shrimp Litopenaeus vannamei. Scientific Reports, 2017, 7: 40549.
4. Yang Yu#, Xiaojun Zhang#, Jianbo Yuan, Fuhua Li, Xiaohan Chen, Yongzhen Zhao, Long Huang, Hongkun Zheng, Jianhai Xiang. Genome survey and high-density genetic map construction provide genomic and genetic resources for the Pacific White Shrimp Litopenaeus vannamei. Scientific Reports, 2015, 5:15612.
5. Yang Yu, Xiaojun Zhang, Jianbo Yuan, Quanchao Wang, Shihao Li, Hao Huang, Fuhua Li*, Jianhai Xiang*. Identification of sex-determining loci in Pacific white shrimp Litopeneaus vannamei using linkage and association analysis. Marine Biotechnology, 2017,19(3): 277–286.
6. Yang Yu, Jiankai Wei, Xiaojun Zhang, Jingwen Liu, Chengzhang Liu, Fuhua Li, Jianhai Xiang. SNP Discovery in the Transcriptome of White Pacific Shrimp Litopenaeus vannamei by Next Generation Sequencing, PLOS ONE, 2014, 9(1): e87218.
7. Yang Yu, Xiaojun Zhang, Jingwen Liu, Fuhua Li, Hao Huang, Yijun Li, Xiaolin Liu, Jianhai Xiang. Molecular markers for identifying a new selected variety of Pacific white shrimp Litopenaeus vannamei. Chinese Journal of Oceanology and Limnology. 2015, 33(1):1-10.
8. Quanchao Wang#, Yang Yu#, Jianbo Yuan, Xiaojun Zhang, Hao Huang, Fuhua Li, Jianhai Xiang. Effects of marker density and population structure on the genomic prediction accuracy for growth trait in Pacific white shrimp Litopenaeus vannamei. BMC genetics. 2017, 18:45 .
9. Quanchao Wang#, Yang Yu#, Qian Zhang, Xiaojun Zhang, Hao Huang, Jianhai Xiang, Fuhua Li. Evaluation on the genomic selection in Litopenaeus vannamei for the resistance against Vibrio parahaemolyticus. Aquaculture, 2019, 505,212-216.
10. Quanchao Wang#, Yang Yu#, Qian Zhang, Xiaojun Zhang, Jianbo Yuan, Hao Huang, Jianhai Xiang, Fuhua Li. A novel candidate gene associated with body weight in the Pacific white shrimp Litopenaeus vannamei. Frontiers in Genetics, 2019; 10: 520 https://doi.org/10.3389/fgene.2019.00520
11. Qian Zhang#, Yang Yu#, Quanchao Wang, Fei Liu, Zheng Luo, Chengsong Zhang, Xiaojun Zhang, Hao Huang, Jianhai Xiang, Fuhua Li. Identification of Single Nucleotide Polymorphisms Related to the Resistance Against Acute Hepatopancreatic Necrosis Disease in the Pacific White Shrimp Litopenaeus vannamei by Target Sequencing Approach. Frontiers in Genetics, 2019; 10: 700.
12. Qian Zhang, Chengsong Zhang, Yang Yu*, Quanchao Wang, Fuhua Li. Characteristic analysis of simple sequence repeats in the ridgetail white prawn Exopalaemon carinicauda genome and its application in parentage assignment. Journal of the World Aquaculture Society. 2020;51:690-701. DOI: 10.1111/jwas.12650 .
13. Yue Jin, Yang Yu*, Chengsong Zhang, Shihao Li, Xiaojun Zhang, Fuhua Li*. Characterization and Function Analysis of the Beta-Carotene Oxygenase-like Genes in Carotenoids Metabolism of the Ridgetail White Prawn Exopalaemon carinicauda. Frontiers in physiology, 2020, 11:745.
14. Quanchao Wang#, Yang Yu#, Qian Zhang, Zheng Luo, Xiaojun Zhang, Jianhai Xiang, Fuhua Li*. The polymorphism of LvMMD2 gene and its association with growth traits in Litopenaeus vannamei. Marine Biotechnology. 2020 22, 564-571.
15. Yang Yu, Zheng Luo, Quanchao Wang, Qian Zhang, Xiaojun Zhang, Jianhai Xiang, Fuhua Li*. Development of high throughput SNP genotyping approach using target sequencing in Pacific white shrimp and its application for genetic study. Aquaculture. 2020, 528:735549.
16. Yue Wang, Yang Yu*, Shihao Li, Xiaojun Zhang, Jianhai Xiang, Fuhua Li*. Sex-specific transcriptome sequencing of Zoea Ⅰ larvae and identification of sex-linked genes using bulked segregant analysis in Pacific white shrimp Litopeneaus vannamei.Marine Biotechnology, 2020,22, 423-432.
17. Ding Lyu, Yang Yu, Qian Zhang, Zheng Luo, Quanchao Wang, Jianhai Xiang, Fuhua Li. Estimating genetic parameters for resistance to Vibrio parahaemolyticus with molecular markers in Pacific white shrimp. Aquaculture. 2020, 527:735439.
18. Zheng Luo, Yang Yu*, Jianhai Xiang, Fuhua Li*. Genomic selection using a subset of SNPs identified by genome-wide association analysis for disease resistance traits in aquaculture species. Aquaculture, 2021, 539, 736620.
19. Yue Wang, Yang Yu*, Shihao Li, Xiaojun Zhang, Fuhua Li*. Analysis of a sex-biased sequence in sex determination region and exploitation of a fast sex detection method in Litopenaeus vannamei. Aquaculture, 2021, 543, 736922.
20. Ding Lyu#, Yang Yu#，Quanchao Wang, Zheng Luo, Qian Zhang, Xiaojun Zhang Jianhai Xiang, Fuhua Li*. Identification of growth-associated genes by genome-wide association study (GWAS) and their potential application in the breeding of Pacific white shrimp (Litopenaeus vannamei). Frontiers in Genetics. 2021, 12:611570.
21. Qian Zhang, Yang Yu*, Zheng Luo, Jianhai Xiang, Fuhua Li*. Comparison of gene expression between resistant and susceptible families against VPAHPND and identification of biomarkers used for resistance evaluation in Litopenaeus vannamei. Frontiers in Genetics. 2021, 12:772442.
22. Zheng Luo, Yang Yu*, Qian Zhang, Zhenning Bao, Jianhai Xiang, Fuhua Li*. Comparative transcriptome analysis reveals the adaptation mechanism to high-salinity in Litopenaeus vannamei. Frontiers in marine science. 2022 ,9:864338.
23. Zheng Luo, Yang Yu*, Zhenning Bao, Jianhai Xiang, Fuhua, Li*. Evaluation of genomic selection for high salinity tolerance traits in Pacific white shrimp Litopenaeus vannamei. Aquaculture, 2022,557,738320.
24. Qian Zhang, Chengsong Zhang, Yang Yu*, Fuhua Li. Analysis of genetic diversity and population structure of the ridgetail white prawn Exopalaemon carinicauda in China. Aquaculture Reports, 2022, 27, 101369.
25. Jianbo Yuan#, Yang Yu#, Xiaojun Zhang, Shihao Li, Jianhai Xiang, Fuhua Li*. Recent advances in crustacean genomics and their potential application in aquaculture. Reviews in Aquaculture, 2023, DOI: 10.1111/raq.12791.
26. 于洋, 李富花, 张晓军, 相建海。一种基于一步PCR技术进行凡纳滨对虾遗传性别鉴定的方法，专利号：ZL 201510245995.2，授权日期：2018.2.13
27. 于洋, 相建海, 李富花, 王全超, 张晓军。一种用于凡纳滨对虾种质鉴定的分子标记组合及其应用，专利号：ZL201610406687.8。授权日期：2019.07.26
28. 于洋，张倩，李富花，张成松。进行脊尾白虾家系鉴定的微卫星标记组合及应用。国家发明专利，专利号：ZL 201811288368.7，申请日：2018.10.31,授权日：2021年8月17日。
29. 于洋，李富花，张晓军，相建海。一种用于凡纳滨对虾分子育种的高通量SNP分型方法。国家发明专利，专利号：ZL201910150705.4，申请日：2019.02.28，授权日：2022年01月07日。
30. 于洋，李富花，张倩，相建海。一种对虾抗弧菌分子标记组合及其在育种中的应用。专利号：201910406987.X，公开号：CN110129456B，申请日：2019.05.16，授权日：2022年5月6日
31. 于洋，李富花，张晓军，相建海。一种与凡纳滨对虾体重性状显著相关的SNP标记和应用。专利号：201910150557.6，申请日：2019.02.28，公开号：CN109971865A，授权日：2022.05.06
32. 于洋，李富花，吕丁，张晓军，相建海。一组对虾生长相关SNP标记及其在育种中的应用。专利号：ZL 202010723188.8，申请日：2020.07.24，授权日：2022年5月6日
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