一、研究领域
1. 海洋天然药物化学;
2. 海洋微生物代谢产物及其功能与调控。
二、招生专业及方向
海洋生物学,海洋生物天然产物及生物制品
三、研究室及联系方式
实验海洋生物学重点实验室;
电话:0532-82898890;
邮箱:lihonglei@qdio.ac.cn。
四、承担的主要科研项目
1. 国家自然科学基金面上项目,基于原位环境关键硫、铁元素导向的深海热液真菌次生代谢产物挖掘与抗肿瘤活性研究,56万元,2023.01–2026.12,主持;
2. 国家自然科学基金青年科学基金项目,基于宿主化学成分诱导和转化的松节藻内生真菌代谢产物分子多样性和抗弧菌活性研究,24万元,2021.01–2023.12,主持;
3. 中国博士后科学基金面上项目,基于宿主海藻培养基的凹顶藻内生真菌次级代谢产物研究,5万元,2018.06–2020.01,主持;
4. 山东省自然科学基金博士基金项目,以海藻为培养基的冈村凹顶藻内生真菌次级代谢产物的化学多样性及其抗水产病害菌的研究,7万元,2018.03–2020.12,主持;
5. 中国科学院沈阳分院-山东省科学院青年科学家合作伙伴项目,药用植物及海洋来源天然抗菌、抗炎活性成分的发现,3万元,2020.01–2022.12,主持;
6. 青岛海洋科学与技术国家实验室开放基金,基于海藻培养基的凹顶藻内生真菌代谢产物化学多样性与抗弧菌活性研究,20万元,2020.01–2022.12,主持。
五、代表性论文及著作
1. Hong-Lei Li, Rui Xu, Xiao-Ming Li, Sui-Qun Yang, Ling-Hong Meng, Bin-Gui Wang. Simpterpenoid A, a meroterpenoid with a highly functionalized cyclohexadiene moiety featuring gem-propane-1,2-dione and methylformate groups, from the mangrove-derived Penicillium simplicissimum MA-332. Org. Lett. 2018, 20, 1465–1468.
2. Hong-Lei Li, Xiao-Ming Li, Attila Mándi, Sándor Antus, Xin Li, Peng Zhang, Yang Liu, Tibor Kurtán, Bin-Gui Wang. Characterization of cladosporols from the marine algal-derived endophytic fungus Cladosporium cladosporioides EN-399 and configurational revision of the previously reported cladosporol derivatives. J. Org. Chem. 2017, 82, 9946−9954.
3. Hong-Lei Li, Xiao-Ming Li, Xin Li, Chen-Yin Wang, Hui Liu, Matthias U. Kassack, Ling-Hong Meng, Bin-Gui Wang. Antioxidant hydroanthraquinones from the marine algal-derived endophytic fungus Talaromyces islandicus EN-501. J. Nat. Prod. 2017, 80: 162−168.
4. Hong-Lei Li, Sui-Qun Yang, Xiao-Ming Li, Xin Li, Bin-Gui Wang. Structurally diverse alkaloids produced by Aspergillus creber EN-602, an endophytic fungus obtained from the marine red alga Rhodomela confervoides. Bioorg. Chem. 2021, 110, 104822.
5. Yan-He Li, Sui-Qun Yang, Xiao-Ming Li, Xin Li, Bin-Gui Wang, Hong-Lei Li. Cyclopiumolides A and B, unusual 13-membered macrolides from the deep sea-sourced fungus Penicillium cyclopium SD-413 with antiproliferative activities. Bioorg. Chem. 2022, 128, 106104.
6. Yan-He Li, Xiao-Ming Li, Xin Li, Sui-Qun Yang, Bin-Gui Wang, Hong-Lei Li. Verrucosidin derivatives from the deep sea cold-deep-derived fungus Penicillium polonicum CS-252. Int. J. Mol. Sci. 2022, 23, 5567.
7. Hong-Lei Li, Xiao-Ming Li, Zhen Ying, Yan-He Li, Bin-Gui Wang. Bisabolane sesquiterpene and cyclopentene derivatives from the marine algal-derived endophytic fungus Trichoderma asperellum EN-764. Phytochemistry 2023, 210, 113644.
8. Yan-He Li, Sui-Qun Yang, Xiao-Ming Li, Xin Li, Bin-Gui Wang, Hong-Lei Li. Five new verrucosidin derivatives from Penicillium polonicum, a deep-sea cold-seep sediment isolated fungus. Fitoterapia 2023, 165, 105387.
9. Zhen Ying, Xiao-Ming Li, Bin-Gui Wang, Hong-Lei Li1, Ling-Hong Meng. Rubensteroid A, a new steroid with antibacterial activity from Penicillium rubens AS-130. J. Antibiot. 2023, 76, 563–566.