生物与医药
李荣锋,男,博士,副研究员,硕士生导师。主要从事海洋活性大分子(蛋白质、多糖等)生物催化与合成、海洋药物研究与开发,以及海洋生物资源高值化利用等研究工作。承担国家自然科学基金、中国科学院STS项目、山东省重点研发计划、山东省自然科学基金、南通市自然科学基金等项目;已发表SCI论文60余篇,出版专著2部,获国家发明授权专利40余项,多项专利实现成果转让;获中国科学院沈阳分院优秀青年科技人才奖、海洋科学技术一等奖(第二位)等。
一、研究领域
1、海洋活性大分子生物催化与合成
2、海洋药物研究与开发
3、海洋生物资源加工与高值化利用
二、招生专业及方向
1、海洋生物学,海洋药物与制品方向
2、生物与医药,海洋生物工程方向
三、研究室及联系方式
研究室:实验海洋生物学重点实验室
联系方式:rongfengli@qdio.ac.cn;0532-82898707
、承担的主要科研项目
1、国家自然科学基金:沙海蜇(Stomoluphus meleagris)毒素蜇伤致死因子及其致死机制研究(41406152),2015/01-2017/12,负责人。
2、国家自然科学基金:沙海蜇抗毒血清对水母毒素的拮抗效应及作用机制研究(41876164),2019/01-2022/12,负责人。
3、山东省重点研发计划:基于组学技术的白色霞水母毒素蜇伤因子的筛选(2015GSF115034),2015/01-2016/12,负责人。
4、山东省自然科学基金:霞水母毒素特异性抗体的解毒效果评测及作用机制研究(ZR2019QD012),2019/07-2022/06,负责人。
5、中国科学院STS项目:利用大黄鱼加工下脚料制备高附加值肽类产品的开发与产业化(2024T3066),2024.05-2027.04,负责人;
6、南通市自然科学基金:岩藻糖化硫酸软骨素介导的内源性抗凝血作用及其分子机制研究(JC2023031),2023.09-2026.08,负责人;
7、横向项目:海参活性肽加工技术与制品开发,2022.02-2025.02, 负责人。
8、横向项目:冰岛海参/北极海参活性肽的加工新技术与生物制品开发,2025.01-2028.01,负责人。
五、研究成果及奖励
1. 中国科学院沈阳分院第五届优秀青年科技人才奖,2016。
2. 海洋科学技术一等奖,2017,水母毒素及蜇伤防治研究,第二完成人。                             
六、代表性论文及著作
1.Li, K., Li, R.*, Liu, Y., Li, G. & Liu, S. Diversity, mechanism and structure-activity relationships of marine anticoagulant-active polysaccharides: A review. International Journal of Biological Macromolecules 306, 141742 (2025).
2.Liu, Y. Li, R.*, et al. Intermediate molecular weight-fucosylated chondroitin sulfate from sea cucumber Cucumaria frondosa is a promising anticoagulant targeting intrinsic factor IXa. Int J Biol Macromol, 131952 (2024).
3.Li, R. & Meng, J. Production of high-value products from the by-products of aquatic food processing, Food and Agriculture Organization of the United Nations (FAO), Rome, Italy, (2024).
4.Li, R*., Yu, H., Li, A., Yu, C. & Li, P*. Identification and characterization of the key lethal toxin from jellyfish Cyanea nozakii. International Journal of Biological Macromolecules 230(2023).
5.Li, R.* & Li, P. High-Value Utilization of Marine Biological Resources. Foods 12, 4054 (2023).
6.Li, R.*, Yu, H., Li, A., Yu, C. & Li, P.* Preparation and Neutralization Efficacy of Novel Jellyfish Antivenoms against Cyanea nozakii Toxins. Toxins 13(2021).
7.Li, R.*, Yu, H., Li, A., Yu, C. & Li, P.* Refinement and Neutralization Evaluation of the F(ab')2 Type of Antivenom against the Deadly Jellyfish Nemopilema nomurai Toxins. International Journal of Molecular Sciences 22(2021).
8.Li, R.*, Yu, H., Li, T. & Li, P.* Comprehensive Proteome Reveals the Key Lethal Toxins in the Venom of Jellyfish Nemopilema nomurai Journal of Proteome Research 19, 2491-2500 (2020).
9.Li, R., Yu, H., Yue, Y. & Li, P.* Combined Proteome and Toxicology Approach Reveals the Lethality of Venom Toxins from Jellyfish Cyanea nozakii. Journal of Proteome Research 17, 3904-3913 (2018).
10.Li, R. et al. Combined proteomics and transcriptomics identifies sting-related toxins of jellyfish Cyanea nozakii. Journal of Proteomics 148, 57-64 (2016).
11.Li, R. et al. Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva. Chinese Journal of Oceanology and Limnology, 1-7 (2016).
12.Li, R. et al. Jellyfish venomics and venom gland transcriptomics analysis of Stomolophus meleagris to reveal the toxins associated with sting. Journal of Proteomics 106, 17-29 (2014).
13.Li, R. et al. In depth analysis of the in vivo toxicity of venom from the jellyfish Stomolophus meleagris. Toxicon 92, 60-65 (2014).
14.Li, R. et al. Isolation and in vitro partial characterization of hemolytic proteins from the nematocyst venom of the jellyfish Stomolophus meleagris. Toxicology in Vitro 27, 1620-1625 (2013).
15.Li, R. et al. Application of nanoLC–MS/MS to the shotgun proteomic analysis of the nematocyst proteins from jellyfish Stomolophus meleagris. Journal of Chromatography B 899, 86-95 (2012).
16.Li, R. et al. Isolation, identification and characterization of a novel antioxidant protein from the nematocyst of the jellyfish Stomolophus meleagris. International Journal of Biological Macromolecules 51, 274-278 (2012).
17.Li, R.* et al. Two-step purification and in vitro characterization of a hemolysin from the venom of jellyfish Cyanea nozakii Kishinouye. International Journal of Biological Macromolecules 49, 14-19 (2011).