张立涛，男，副研究员，硕士研究生导师。长期聚焦藻类生物技术领域，致力于从分子调控与生理响应层面挖掘微藻的工业应用潜力。目前已发表学术论文100余篇，获得授权专利17项，主持包括国家重点研究计划、国家自然科学基金等在内的省部级项目9项。

一、研究领域  

1. 微藻次生代谢调控——以红球藻为模式，系统解析环境胁迫信号驱动虾青素高效积累的调控网络与关键限速步骤，探索光-碳耦合强化策略。

2. 藻类光合生理与逆境适应——关注微藻在高温、高盐及高光胁迫下的光保护机制，阐明光合电子传递重定向对碳流分配的影响。

3. 微藻生物能源——围绕能源微藻，通过代谢工程优化合成通路，提升油脂和氢气产率，为微藻高值化利用和绿色能源转化提供理论依据与工程化方案。

二、招生专业及方向

1. 学硕：海洋生物学——生理、生化过程与调控

2. 专硕：生物与医药——海洋生物工程

三、研究室及联系方式       

研究室：实验海洋生物学重点实验室

邮箱：zhanglitao@qdio.ac.cn

电话：0532-82876007 

四、承担的主要科研项目

1. 国家自然科学基金面上项目，高山气生橘色藻抵御光系统I低温光抑制的机制（32570419），主持。

2. 国家自然科学基金面上项目，甘油缓解红球藻光系统I低温光抑制的机制（32370409），主持。

3. 国家重点研发计划课题，红球藻碳代谢流的分配及调控—微藻高效供碳和高值化产品关键技术开发与示范（2018YFE0107200），主持。

4. 国家自然科学基金面上项目，小分子有机物GL缓解红球藻光抑制并促进虾青素积累的机制（31872588），主持。

5. 国家重点研发计划子课题，微藻固碳培养过程中病虫害无公害防治关键技术研究（2016YFB0601004-03），主持。

五、研究成果及奖励         

主持研发的小分子有机物兼养培养技术在提高微藻高附加值产物含量的同时，可有效缓解户外强光对微藻的破坏；负责研发的微藻敌害生物防治技术拥有自主知识产权，处于国际领先水平；此外，解析了微藻初生代谢途径（光合作用、呼吸作用等）对次生代谢（虾青素合成）及产能过程（光合产氢和油脂产生）的独特调控机制。

六、代表性论文及著作

1. Yu Wenjie, Zhang Litao, Liang Shan, Liu Jianguo (2026) Glutamate and glutamine enable rapid acclimation of Haematococcus lacustris to high‐light during culture phase shift by pre-activating photoprotective pathways. Plant, Cell & Environment, 49: 891-905.

2. Guo Shujiu, Yang Na, Yu Wenjie, Zhang Litao, Liu Jianguo (2026) Haematococcus pluvialis residues derived deep red emissive carbon dots for ultrasensitive and selective Cu2+ detection in seawater. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 348: 127201.

3. Liang Shan, Yu Wenjie, Li Jing, Liu Jianguo, Zhang Litao (2026) Mechanistic insights into diclofenac-induced photosynthetic damage in Haematococcus pluvialis: Implications for ecological risk of NSAID pollution. Algal Research, 96: 104721.

4. Li Jing, Zhang Litao, Yu Wenjie, Chen Feng, Tsygankov Anatoly, Liu Jianguo (2025) The transition between germination and dormancy of non-motile cells in Haematococcus pluvialis: dependence on nitrogen availability through the metabolic flux of amino acids and nucleotides. Bioresource Technology, 434: 132818.

5. Zhang Mengjie, Zhang Litao, Li Hu, Li Jing, Luan Weiying, Li Zihao, Liu Jianguo (2025) The alternative oxidase pathway participates in seagrass seedling establishment by regulating photosynthetic and respiratory metabolism. Physiologia Plantarum, 177: e70302.

6. Zhang Litao, Zhang Chunhui, Xu Ran, Yu Wenjie, Liu Jianguo (2022) A strategy for promoting carbon flux into fatty acid and astaxanthin biosynthesis by inhibiting the alternative oxidase respiratory pathway in Haematococcus pluvialis. Bioresource Technology, 344: 126275.

7. Zhang Litao, Li Ling, Liu Jianguo (2022) Enhanced biohydrogen and lipid coproduction in Chlorella protothecoides under nitrogen-limiting conditions in a closed system. Journal of Cleaner Production, 359: 132169.

8. Xu Ran, Zhang Litao, Yu Wenjie, Liu Jianguo (2022) A strategy for interfering with the formation of thick cell walls in Haematococcus pluvialis by down-regulating the mannan synthesis pathway. Bioresource Technology, 362: 127783.

9. Yu Wenjie, Zhang Litao, Zhao Jing, Liu Jianguo (2022) Enhancement of astaxanthin accumulation in Haematococcus pluvialis by exogenous oxaloacetate combined with nitrogen deficiency. Bioresource Technology, 345: 126484.

10. Yu Wenjie, Zhang Litao, Zhao Jing, Liu Jianguo (2021) Exogenous sodium fumarate enhances astaxanthin accumulation in Haematococcus pluvialis by enhancing the respiratory metabolic pathway. Bioresource Technology, 341: 125788.