生物与医药
刘媛,女,1983年9月生,理学博士,研究员,硕士生导师。
主要从事甲壳动物分子遗传学和免疫学研究。先后主持承担了国家自然科学基金青年项目和面上项目、“蓝色粮仓科技创新”重点专项子课题、国家科技支撑计划子课题、山东省自然科学基金、青岛市源头创新计划等课题。发表第一作者和通讯作者SCI论文20余篇,授权发明专利6项,软件著作权1项,获批水产新品种1个。以共同一作(第2位)发表在Nature子刊Nature Communications上的文章浏览次数超3000次,发表在Heredity的文章入选 2015年“ESI热点论文”。
一、研究领域  
甲壳动物免疫防御的分子机制、甲壳动物性别分化的分子遗传学基础
二、招生专业及方向
学术型:海洋生物学—免疫学基础及应用
专业型:生物与医药
三、研究室及联系方式       
实验海洋生物学重点实验室
邮箱liuyuan@qdio.ac.cn;电话0532-82898637
四、承担的主要科研项目
(1) 主持国家自然科学基金面上项目:三疣梭子蟹补体凝集素激活途径及介导的母源免疫机制研究(41776159),2017.10-2021.12,71万元;
(2) 主持国家重点研发计划子课题:蟹类良种创制与繁育关键技术(Y92438101W),2018.12-2022.12,52万元;
(3) 主持国家自然科学基金青年基金:三疣梭子蟹丝氨酸蛋白酶功能多样性及其调控机制(41206147),2012.10-2015.12,经费25万元。
五、研究成果及奖励         
在甲壳动物经济性状调控机制和种质资源利用方面取得一系列成果。先后荣获青岛市自然科学二等奖(排名2)、海洋科学技术二等奖(排名2)、山东省自然科学三等奖(排名3)、辽宁省科技进步一等奖(排名4)、教育部科技进步二等奖(排名5)、宁波市科学技术二等奖(排名5)和中华农业科技一等奖(排名7)等 。
六、代表性论文及著作
(1) Zhaoxia Cui#, Yuan Liu#, Jianbo Yuan#, Xiaojun Zhang#, Tomer Ventura#, Ka Yan Ma, Shuai Sun, Chengwen Song, Dongliang Zhan, Yanan Yang, Hourong Liu, Guangyi Fan, Qingle Cai, Jing Du, Jing Qin, Chengcheng Shi, Shijie Hao, Quinn P. Fitzgibbon, Gregory G. Smith, Jianhai Xiang, Tin-Yam Chan, Min Hui, Chenchang Bao, Fuhua Li & Ka Hou Chu. 2021. The Chinese mitten crab genome provides insights into adaptive plasticity and developmental regulation. Nature communications 12:2395 (#contributed equally to this work).
(2) Yuan Liu*, Yue Su, Ao Zhang, Zhaoxia Cui. 2021. A C-type lectin highly expressed in Portunus trituberculatus intestine functions in AMP regulation and prophenoloxidase activation. Antibiotics 10: 541.
(3) Yue Su, Yuan Liu*, Fengtao Gao, Zhaoxia Cui. 2020. A novel C-type lectin with a YPD motif from Portunus trituberculatus (PtCLec1) mediating pathogen recognition and opsonization. Developmental and Comparative Immunology 106:103609.
(4) Junhao Ning, Yuan Liu*, Fengtao Gao, Hourong Liu, Zhaoxia Cui. 2019. Characterization and functional analysis of a novel gC1qR in the swimming crab Portunus trituberculatus. Fish & Shellfish Immunology 84:970-978.
(5) Hourong Liu, Yuan Liu*, Chengwen Song, Zhaoxia Cui. 2017. A chymotrypsin-like serine protease from Portunus trituberculatus involved in pathogen recognition and AMP synthesis but not required for prophenoloxidase activation. Fish and Shellfish Immunology. 66: 307-316. 
(6) Peiyao Li, Yuan Liu*, Danli Luo, Chengwen Song, Zhaoxia Cui. 2017. Two spliced isoforms of the sex-determination gene fruitless in the Chinese mitten crab Eriocheir sinensis. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 208:75-83. 
(7) Yuan Liu, Guohui Shi, Zhaoxia Cui, Danli Luo, Chengwen Song, Xihong Li, Min Hui, Yingdong Li. 2014. PtSerpin from the swimming crab Portunus trituberculatus, a putative regulator of prophenoloxidase activation with antibacterial activity. Fish & Shellfish Immunology 39:365-371. 
(8) Yuan Liu, Min Hui, Zhaoxia Cui, Danli Luo, Chengwen Song, Yingdong Li, Lei Liu. 2015. Comparative transcriptome analysis reveals sex-biased gene expression in juvenile Chinese mitten crab Eriocheir sinensis. PLoS One 10: e0133068. 
(9) Yuan Liu, Zhaoxia Cui, Guohui Shi, Danli Luo, Shuangyan Wang, Chunlin Wang. 2015. PtPLC, a pacifastin-related inhibitor involved in antibacterial defense and prophenoloxidase cascade of the swimming crab Portunus trituberculatus. Fish & Shellfish Immunology 43:36-42.
(10) Zhaoxia Cui#, Min Hui#, Yuan Liu#, Chengwen Song, Xihong Li, Yingdong Li, Lei Liu, Guohui Shi, Shi Wang, Fuhua Li, Xiaojun Zhang, Chengzhang Liu, Jianhai Xiang, Ka Hou Chu. 2015. High-density linkage mapping aided by transcriptomics documents ZW sex determination system in the Chinese mitten crab Eriocheir sinensis. Heredity 115:206-215 (# contributed equally to this work).