主要从事海洋动物免疫调控机制研究，揭示了焦孔素介导炎症反应的调控机制与免疫效应，查明了细胞焦亡在抗感染免疫中的作用机理，解析了含DM9结构域的新型免疫识别受体的晶体结构与免疫功能。研究成果发表于Science Immunology(封面文章)、Cell Reports、eLife、Journal of Immunology等国际知名期刊，主持国家自然科学基金、山东省自然科学基金等项目10余项。

本实验室以鱼类等重要海洋动物为研究对象，采用生物化学与分子生物学、细胞生物学、免疫学等实验技术与方法，探究免疫调控机制与抗感染免疫应答机理。研究方向包括：

1.病原感染的分子机制与信号转导；

2.细胞程序性死亡的分子机制及其免疫调控；

3.抗细菌/病毒免疫活性因子功能与机制解析；

1. 招生面向以下本科专业(包括但不限于)：

海洋生物、生命科学、生物技术、生物工程、水产养殖、动物医学等

2. 研究生报考专业及方向：

(1)博士研究生（有志于科研）

海洋生物学，免疫学基础与应用

水产养殖，养殖遗传学与育种生物技术

(2)硕士研究生（有志于科研，有读博意向优先）

海洋生物学，免疫学基础与应用

水产养殖，养殖遗传学与育种生物技术

生物与医药，海洋生物工程

3. 实验室长期招聘特别研究助理(含博士后)2-3名，欢迎对病原感染与宿主免疫感兴趣的有志青年加入。应聘者请提交本人简历(包括个人基本情况、学历学位证明、工作经历、科研成果、特色实验技能等)到sjiang@qdio.ac.cn，邮件主题请标明：姓名+应聘博士后。

4. 每年拟接收2-3名本科生寒暑假实习或毕业设计。

三、研究室及联系方式 

实验海洋生物学重点实验室；邮箱：sjiang@qdio.ac.cn

1.S. Jiang, Z. Zhou, Y. Sun, T. Zhang, and L. Sun, Coral gasdermin triggers pyroptosis. Science Immunology, 2020. 5(54). (封面文章)

2.K. Qin, S. Jiang, H. Xu, Z. Yuan, and L. Sun, Pyroptotic gasdermin exists in Mollusca and is vital to eliminating bacterial infection. Cell Reports, 2023. 42(5): p. 112414.

3.H. Xu, Z. Yuan, K. Qin, S. Jiang, and L. Sun, The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation. eLife, 2023. 12:RP89974. https://doi.org/10.7554/eLife.89974.2. 

4.H. Xu, S. Jiang, C. Yu, Z. Yuan, and L. Sun, GSDMEa-mediated pyroptosis is bi-directionally regulated by caspase and required for effective bacterial clearance in teleost. Cell Death & Disease, 2022. 13(5): p. 491.

5.S. Jiang, H. Gu, Y. Zhao, and L. Sun, Teleost Gasdermin E Is Cleaved by Caspase 1, 3, and 7 and Induces Pyroptosis. Journal of Immunology, 2019. 203(5): p. 1369-1382.

6.X. Tian, Y. Sun, S. Jiang, Apoptotic and proinflammatory caspases orchestrate necrotic cell death by cleaving three gasdermin orthologs in the highly adaptable killifish. Water Biology and Security. 2025, 100409.

7.X. Tian, S. Jiang, Caspase 3 proteolytically inactivates gasdermin Ec and inhibits pyroptosis in an early vertebrate. Comparative Immunology Reports. 

8.Jiang, S., K. Qin and L. Sun, Time-lapse live-cell imaging of pyroptosis by confocal microscopy. STAR Protoc, 2023. 4(4): p. 102708.

9.S. Jiang, L. Wang, M. Huang, Z. Jia, T. Weinert, E. Warkentin, C. Liu, X. Song, H. Zhang, J. Witt, L. Qiu, G. Peng, and L. Song, DM9 Domain Containing Protein Functions As a Pattern Recognition Receptor with Broad Microbial Recognition Spectrum. Frontiers in Immunology, 2017. 8.

10.S. Jiang, L. Qiu, L. Wang, Z. Jia, Z. Lv, M. Wang, C. Liu, J. Xu, and L. Song, Transcriptomic and Quantitative Proteomic Analyses Provide Insights Into the Phagocytic Killing of Hemocytes in the Oyster Crassostrea gigas. Frontiers in Immunology, 2018. 9: p. 1280.

11.Hao, K., H. Xu, S. Jiang, and L. Sun, Paralichthys olivaceus MLKL-mediated necroptosis is activated by RIPK1/3 and involved in anti-microbial immunity. Front Immunol, 2024. 15: p. 1348866.

12.X. Li, S. Jiang and L. Sun, Tongue sole creatine kinases function as DAMP and activate antimicrobial immunity via TLR2. Frontiers in Immunology, 2023. 14: p. 1142488.

13.Z. Yuan, S. Jiang, K. Qin, and L. Sun, New insights into the evolutionary dynamic and lineage divergence of gasdermin E in metazoa. Frontiers in Cell and Developmental Biology, 2022. 10: p. 952015.

14.S. Jiang. and L. Sun, Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis. International Journal of Molecular Sciences, 2017. 18(9).

15.T. Zhang, S. Jiang and L. Sun, A Fish Galectin-8 Possesses Direct Bactericidal Activity. International Journal of Molecular Sciences, 2020. 22(1). 

16.S. Jiang, Z. Jia, H. Chen, L. Wang, and L. Song, The modulation of haemolymph arginine kinase on the extracellular ATP induced bactericidal immune responses in the Pacific oyster Crassostrea gigas. Fish & Shellfish Immunology, 2016. 54: p. 282-93.

17.S. Jiang, Z. Jia, L. Xin, Y. Sun, R. Zhang, W. Wang, L. Wang, and L. Song, The cytochemical and ultrastructural characteristics of phagocytes in the Pacific oyster Crassostrea gigas. Fish & Shellfish Immunology, 2016. 55: p. 490-8. 

18.S. Jiang, H. Li, D. Zhang, H. Zhang, L. Wang, J. Sun, and L. Song, A C1q domain containing protein from Crassostrea gigas serves as pattern recognition receptor and opsonin with high binding affinity to LPS. Fish & Shellfish Immunology, 2015. 45(2): p. 583-91.

19.J. Tong, X. Guan, S. Jiang, and L. Sun, A saposin domain-containing protein of tongue sole Cynoglossus semilaevis: Antimicrobial activity and mechanism. Developmental & Comparative Immunology, 2023. 141: p. 104633. 

20.S. Jiang, Z. Jia, T. Zhang, L. Wang, L. Qiu, J. Sun, and L. Song, Functional characterisation of phagocytes in the Pacific oyster Crassostrea gigas. PeerJ, 2016. 4: p. e2590.