霍达，女，副研究员，硕士生导师。长期专注于“全球变化下关键海参类物种的响应与适应机制”研究，聚焦海参外泌体、非编码RNA及单双呼吸体系等在逆境中的调控作用与适应机制。共计发表SCI论文30余篇于Environmental Pollution、Science of The Total Environment、Molecular Ecology、Ecotoxicology and Environmental Safety等期刊，其中以第一作者、通讯作者（含共同）发表SCI论文17篇（均为Q1或Q2）。主持国家自然科学青年基金、国家重点研发计划子课题、山东省博士后创新人才支持计划、中国科学院特别研究助理资助项目等项目及课题。参编中文专著3部、英文专著1部、Ebook1部。授权国内发明专利2项、国际发明专利1项、申请发明专利5项。入选山东省人才项目，获省部级一等奖1项，获中国科学院院长特别奖、中国科学院优秀博士学位论文等奖励及荣誉。担任中国自然资源学会海洋资源专业委员会副秘书长，以及ISME Communications、Science of the Total Environment、iMeta、Aquaculture、Marine Environmental Research、Marine Biotechnology等多个SCI期刊的编委和审稿人。

一、研究领域  

研究领域为水生生物逆境生物学。率先在无脊椎动物刺参中优化分离并鉴定出外泌体，解析了其在环境胁迫下的响应特征及功能；构建了系统生物学背景下刺参感知复合胁迫（高温、低氧、酸化等）的复杂应激调节网络；探明了刺参单双呼吸体系转换（吐脏行为），解析了其在逆境下生理及分子层面响应特征；关注海参安全度夏、健康养殖、保活运输等关键产业难题，支撑产业良性发展。           

学术型硕士：海洋生态学，养殖生态学方向；水产养殖，养殖遗传学与育种生物技术方向

专业型硕士：生物与医药，海洋生物工程方向

三、研究室及联系方式       

海洋生态与环境科学重点实验室

邮箱：huoda@qdio.ac.cn 

电话：0532-82898705

共计承担项目9项，其中省部级及以上项目7项。

1. 国家重点研发计划，地球系统与全球变化重点专项，2022.12-2027.11，64万元，子课题负责人

2. 国家自然科学基金青年项目，国家自然科学基金委，2022.01-2024.12，30万元，项目负责人

3. 山东省泰山学者青年专家项目，中共山东省委人才工作领导小组，2023.01-2025.12，75万元，项目负责人

4. 山东省自然科学基金，山东省科学技术厅，2022.01-2024.12，15万元，项目负责人

5. 山东省博士后创新人才支持计划，山东省人力资源和社会保障厅，2021.01-2022.12，40万元，项目负责人

6. 中国科学院特别研究助理资助项目，中国科学院人事局，2021.01-2022.12，60万元，项目负责人

7. 中国博士后科学基金面上项目，中国博士后科学基金会，2020.11-2022-07，8万元，项目负责人

五、研究成果及奖励         

入选山东省人才项目，获省部级一等奖1项（11/15）、中国科学院院长特别奖、中国科学院优秀博士学位论文、北京市高等学校优秀毕业生等奖励及荣誉。

第一作者代表性论文：

1. Huo D, Zhang L, Yang H, Sun L*. Adaptation to hypoxic stress involves amino acid metabolism: A case in sea cucumber[J]. Environmental Pollution, 2023, 330: 121766.

2. Huo D, Sun L*, Sun J, Zhang L, Liu S, Su F, Yang H. Sea cucumbers in a high temperature and low dissolved oxygen world: Roles of miRNAs in the regulation of environmental stresses[J]. Environmental Pollution, 2021, 268: 115509.

3. Huo D, Sun L*, Storey K B, Zhang L, Liu S, Sun J, Yang H*. The regulation mechanism of lncRNAs and mRNAs in sea cucumbers under global climate changes: Defense against thermal and hypoxic stresses[J]. Science of the Total Environment, 2020, 709: 136045.

4. Huo D, Su F, Yang H, Sun L*. Exosomal microRNAs regulate the heat stress response in sea cucumber Apostichopus japonicus[J]. Ecotoxicology and Environmental Safety, 2023, 249: 114419.

5. Huo D, Sun L*, Sun J, Lin C, Liu S, Zhang L, Yang H. Emerging roles of circRNAs in regulating thermal and hypoxic stresses in Apostichopus japonicus (Echinodermata: Holothuroidea)[J]. Ecotoxicology and Environmental Safety, 2021, 228: 112994.

6. Huo D, Liu S, Zhang L, Yang H, Sun L*. Importance of the ECM-receptor interaction for adaptive response to hypoxia based on integrated transcription and translation analysis. Molecular Ecology, 2024, 00, e17352. 

7. Huo D, Su F, Cui W, Liu S, Zhang L, Yang H, Sun L*. Heat stress and evisceration caused lipid metabolism and neural transduction changes in sea cucumber: Evidence from metabolomics[J]. Marine Pollution Bulletin, 2022, 182: 113993.

8. Huo D, Sun L*, Zhang L, Ru X, Liu S, Yang H*. Metabolome responses of the sea cucumber Apostichopus japonicus to multiple environmental stresses: Heat and hypoxia[J]. Marine Pollution Bulletin, 2019, 138: 407-420.

9. Huo D, Sun L*, Zhang L, Ru X, Liu S, Yang X, Yang H*. Global-warming-caused changes of temperature and oxygen alter the proteomic profile of sea cucumber Apostichopus japonicus[J]. Journal of Proteomics, 2019, 193: 27-43.

10. Huo D, Sun L*, Zhang L, Yang H*, Liu S, Sun J, Su F. Time course analysis of immunity-related gene expression in the sea cucumber Apostichopus japonicus during exposure to thermal and hypoxic stress[J]. Fish & shellfish immunology, 2019, 95: 383-390.

其他作者代表性论文：

1.Jin W, Li T, Huo D, et al. Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome. Cell, 2022, 185 (3), 547-562. 

2.Li T, Chen X, Huo D, Arifuzzaman M, Qiao S, Jin W, Shi H, Li X, JRI Live Cell Bank, Iliev I, Artis D, Guo C, Microbiota metabolism of intestinal amino acids impacts host nutrient homeostasis and physiology. Cell host & Microbe, 2024, 32(5): 661-675. e10. 

3.Zhang X, Sun L, …, Huo D, …& Yang H. The sea cucumber genome provides insights into morphological evolution and visceral regeneration. PLoS Biology, 2017, 15(10): e2003790. 

4.Song M#, Huo D#, Pang L, et al. Effects of seawater acidification and warming on morphometrics and biomineralization-related gene expression during embryo-larval development of a lightly-calcified echinoderm. Environmental Research, 2024, 248: 118248. 

5.Liu B, Huo D*, Gaitán-Espitia J D, …, & Zhang L*. Multiple-stressor effects of ocean warming, acidification and hypoxia on the locomotor behavior of sea cucumber Apostichopus japonicus[J]. Aquaculture, 2025: 742366.

6.Mohsen M, …, Huo D, & Yang H. Mechanism underlying the toxicity of the microplastic fibre transfer in the sea cucumber Apostichopus japonicus. Journal of Hazardous Materials, 2021, 416, 125858. 

7.Su F, Huo D, Yang H, & Sun L. CircRNA8388 functions as the sponge for miR-2392 during intestinal regeneration in sea cucumber Apostichopus japonicus. International Journal of Biological Macromolecules, 2024, 133302.

8.Ding K, Zhang L, Huo D, …& Zhang S. Metabolomic analysis of coelomic fluids reveals the physiological mechanisms underlying evisceration behavior in the sea cucumber Apostichopus japonicus. Aquaculture, 2021, 736960.

9.Zhao H, Huo D, Cui W, Jiang C, Liu S, Rasoamananto I, ... & Sun L. (2025). Genome-wide association analysis provides genetic insights into variation of nutritional quality traits in sea cucumber Apostichopus japonicus. Journal of Oceanology and Limnology, 1-14.

10.Zhang L, Feng Q, …, Huo D, ... & Yang H. Differential gene expression in the intestine of sea cucumber (Apostichopus japonicus) under low and high salinity conditions. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2018, 25, 34-41. 

著作：

1. 现代海洋牧场探索与实践，2025.06，ISBN：978-7-03-082279-6，参编

2. 现代渔业科技创新发展现状与展望，2023.03，ISBN：9787030724045，参编

3. 海洋牧场知识科普问答，2023.06，ISBN：987-7-109-30104-7，参编

4. The adaptation and response of aquatic animals in the context of global climate change，2023.07，ISBN：978-2-8325-3061-0，参编