李莉，博士，博导，中国科学院海洋研究所研究员，中国科学院大学教授，国家高层次人才特殊支持计划领军人才（万人领军）、科技部创新人才推进计划中青年科技创新领军人才、农业农村部-国家贝类产业技术体系岗位科学家、曾呈奎海洋科技奖获得者。先后在中国科学院海洋研究所任职助理研究员、副研究员以及研究员，曾在美国新泽西州立大学和美国弗吉尼亚州立大学进行博士与博士后研究。

一、 研究领域  

近年来瞄准国家需求与学科前沿，理论与应用研究相结合，致力于海洋生命科学认知与牡蛎等贝类资源的保护与可持续利用。具体围绕牡蛎等贝类的经济与生态服务功能，利用基因组学、遗传学与分子生物学手段，结合海洋生态学及进化等多学科，开展贝类适应进化、经济性状的遗传解析与分子育种等研究。              

二、招生专业及方向

1）海洋生物学, 2）水产养殖

欢迎生物（技术）、水产养殖、生态、食品等相关方向的本科生咨询与实习

三、研究室及联系方式       

山东省青岛市南海路7号，中国科学院海洋研究所实验海洋生物学重点实验室（6号楼3楼）。邮编：266071；E-mail: lili@qdio.ac.cn, 电话：0532-8289 8695

四、承担的主要科研项目

贝类耐高温低氧与抗病性状的遗传关联机制，牡蛎耐高温新品种培育及应用(国家重点研发计划)，贝类环境胁迫疾性疾病防控（农业部贝类产业技术体系），长牡蛎野生群体适应性分化及其机制（自然基金），服务于“美丽海洋”的生物调控技术与示范（中科院先导专项子课题），高品质牡蛎产出关键技术研发与应用示范（山东省重大科技创新工程项目）等多项国家级与省部级课题。                     

五、研究成果及奖励  

发表SCI论文140余篇，其中第一与通讯作者论文80余篇，代表性成果发表在Nature（IF=64.8），Nature Ecology & Evolution（IF=16.8），Molecular Biology and Evolution（2篇，IF=10.2）,the Innovation(IF=32.1)等国际顶级期刊。成果他引3000余次。授权国家发明专利 30余件、获批3项国审水产新品种。荣获2016年2018年度中国海洋与湖沼十大科技进展，荣获山东省自然科学奖二等奖和海洋科学技术奖一等奖各1项。多项成果获得应用转化。                            

六、代表性论文及著作

1) Ao Li, Mingjie Zhao, Ziyan Zhang, Chaogang Wang, Kexin Zhang, Xu Zhang, De Wit Pierre Raoul, Wei Wang, Juntao Gao, Ximing Guo, Guofan Zhang, Li Li*, Genome architecture and selective signals compensatorily shape plastic response to a new environment. Innovation (Cambridge (Mass.)), 2023. 4(4): p. 100464-100464. (IF=32.1)

2) Chaogang Wang, Ao Li, Rihao Cong, Haigang Qi, Wei Wang, Guofan Zhang, Li Li*, Cis- and Trans-variations of Stearoyl-CoA Desaturase Provide New Insights into the Mechanisms of Diverged Pattern of Phenotypic Plasticity for Temperature Adaptation in Two Congeneric Oyster Species. Molecular Biology and Evolution, 2023. 40(2). (IF=10.7)

3) Kexin Zhang, Qi Yang, MingyanDu g, Ziyan Zhang, Wei Wang, Guofan Zhang, Ao Li, Li Li*, Genome-wide mapping of regulatory variants for temperature- and salinity-adaptive genes reveals genetic basis of genotype-by-environment interaction in Crassostrea ariakensis. Environmental Research, 2023. 236. (IF=8.3)

4) Mingkun Liu, Qingyuan Li, Lintao Tan, Luping Wang, FucuWu , Li Li*, Guofan Zhang, Host-microbiota interactions play a crucial role in oyster adaptation to rising seawater temperature in summer. Environmental Research, 2023. 216. (IF=8.3)

5) Xinxing Wang, Rihao Cong, Ao Li, Wei Wang, Guofan Zhang, Li Li*, Transgenerational effects of intertidal environment on physiological phenotypes and DNA methylation in Pacific oysters. Science of the Total Environment, 2023. 871. (IF=9.8)

6）Chaogang Wang, Mingyang Du, Zhuxiang Jiang, Rihao Cong, Wei Wang, Guofan Zhang, Li Li*, Comparative proteomic and phosphoproteomic analysis reveals differential heat response mechanism in two congeneric oyster species. Ecotoxicology and Environmental Safety, 2023. 263(115197). (IF=6.8)

7) Ao Li, Li Li*, Ziyan Zhang, Shiming Li, Wei Wang, Ximing Guo and Guofan Zhang*. Noncoding variation and transcriptional plasticity promote thermal adaptation in oysters by altering energy metabolism. Molecular Biology and Evolution, 2021, msab241. (IF=10.7)

8) Li Li#, Ao Li#, Kai Song#, Jie Meng#, Ximing Guo#, Shiming Li#, Chunyan Li, Pierre De Wit, Huayong Que, Fucun Wu, Wei Wang, Haigang Qi, Fei Xu, Rihao Cong, Baoyu Huang, Yingxiang Li, Ting Wang, Xueying Tang, Sheng Liu, Busu Li, Ruihui Shi, Youli Liu, Chen Bu, Chi Zhang, Weiming He, Shancen Zhao, Hongjun Li, Shoudu Zhang, Linlin Zhang and Guofan Zhang *. Divergence and plasticity shape adaptive potential of the Pacific oyster. Nature Ecology & Evolution, 2018. 2(11): p. 1751-1760.（IF：16.8）

9) Guofan Zhang#*, Xiaodong Fang#, Ximing Guo#*, Li Li#, Ruibang Luo#, Fei Xu#, Pengcheng Yang#, Linlin Zhang#, Xiaotong Wang#, Haigang Qi, Zhiqiang Xiong, Huayong Que, Yinlong Xie, Peter W. H. Holland, Jordi Paps, Yabin Zhu, Fucun Wu, Yuanxin Chen, Jiafeng Wang, Chunfang Peng, Jie Meng, Lan Yang, Jun Liu, Bo Wen, Na Zhang, Zhiyong Huang, Qihui Zhu, Yue Feng, Andrew Mount, Dennis Hedgecock, Zhe Xu, Yunjie Liu, Tomislav Domazet-Loso, Yishuai Du, Xiaoqing Sun, Shoudu Zhang, Binghang Liu, Peizhou Cheng, Xuanting Jiang, Juan Li, Dingding Fan, Wei Wang, Wenjing Fu, Tong Wang, Bo Wang, Jibiao Zhang, Zhiyu Peng, Yingxiang Li, Na Li, Jinpeng Wang, Maoshan Chen, Yan He, Fengji Tan, Xiaorui Song, Qiumei Zheng, Ronglian Huang, Hailong Yang, Xuedi Du, Li Chen, Mei Yang, Patrick M. Gaffney, Shan Wang, Longhai Luo, Zhicai She, Yao Ming, Wen Huang, Shu Zhang, Baoyu Huang, Yong Zhang, Tao Qu, Peixiang Ni, Guoying Miao, Junyi Wang, Qiang Wang, Christian E. W. Steinberg, Haiyan Wang, Ning Li, Lumin Qian, Guojie Zhang, Yingrui Li, Huanming Yang, Xiao Liu, Jian Wang, Ye Yin*, Jun Wang*. The oyster genome reveals stress adaptation and complexity of shell formation. Nature, 2012. 490(7418): p. 49-54. （IF：64.8）

10) Ao Li, He Dai, Ximing Guo, Ziyan Zhang, Kexin Zhang, Chaogang Wang, Xinxing Wang, Wei Wang, Hongju Chen, Xumin Li, Hongkun Zheng, Li Li* and Guofan Zhang*. Genome of the estuarine oyster provides insights into climate impact and adaptive plasticity. Communications Biology, 2021, 10.1038/s42003-021-02823-6. (IF=5.9 )

11）Ziyan Zhang, Ao Li, Zhicai She, Xuegang Wang, Zhen Jia, Wei Wang, Guofan Zhang and Li Li*. Adaptive divergence and underlying mechanisms in response to salinity gradients between two Crassostrea oysters revealed by phenotypic and transcriptomic analyses. Evolutionary Applications, 2022, 10.1111/eva.13370. (IF=4.1)

11) Xinxing Wang, Ao Li, Wei Wang, Guofan Zhang, Li Li*. Direct and heritable effects of natural tidal environments on DNA methylation in Pacific oysters (Crassostrea gigas). Environmental Research, 2021,197:111058.6 . (IF= 6.498)      

12) Xueying Tang, Baoyu Huang, Siheng Lin, Wei Wang, Guofan Zhang, Li Li*. CgMyD88s Serves as an Innate Immune System Plug During Ostreid Herpesvirus 1 Infection in the Pacific Oyster (Crassostrea gigas). Frontiers in Immunology. 2020, 11:1247. (IF= 7.561)

13) Ao Li, Li Li*, Wei Wang and Guofan Zhang. Evolutionary trade-offs between baseline and plastic gene expression in two congeneric oyster species. Biology Letters, 2019. 15(6), 20190202.(IF=3.3)

14) Jiafeng Wang, Haigang Qi, Li Li*, Huayong Que, Di Wang, Guofan Zhang*. Discovery and validation of genic single nucleotide polymorphisms in the Pacific oyster Crassostrea gigas. Molecular Ecology Resources, 2015. 15(1): p. 123-135. （IF=7.7)

14) Haigang Qi, Li Li*, Guofan Zhang*. Construction of a chromosome-level genome and variation map for the Pacific oyster Crassostrea gigas. Molecular Ecology Resources. 2021, 21: 1670-1685.  （IF=7.7 )   

15) Yingxiang Li, Linlin Zhang, Tao Qu, Xueying Tang, Li Li*, Guofan Zhang*. Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas. Cell Death & Disease, 2017. 8: p. 13. (IF= 9.7）