岳洋，男，副研究员，硕士生导师，研究组副组长。研究方向为海洋药物与生物制品，主要聚焦高血压、血栓、慢性肾病等重大慢性疾病，利用人工智能技术高效筛选、智能设计具有治疗潜力的海洋候选多肽分子，并进行成药性优化和功能评价。目前承担国家自然科学基金、山东省自然科学基金、福建省区域发展项目等科研项目9项，以第一作者、通讯作者在Int. J. Biol. Macromol.、Food Res. Int.、Chem.-Biol. Interact.等国际期刊发表SCI论文18篇（含封面论文1篇）；以第一发明人申请国家发明专利5件，已授权2件；获得海洋科学技术奖一等奖1项。现任《海洋科学》青年编委，同时担任Phytomedicine、Int. J. Biol. Macromol.、Food Res. Int.、Toxicol. Sci.、LWT等国际知名期刊的审稿专家。

一、研究领域  

1. 海洋活性肽的结构与功能

2. 人工智能(AI)与多肽药物设计

3. 海洋药物与功能制品的研究与开发

二、招生专业及方向

1.学术型硕士：海洋生物学，海洋药物与制品方向；

2.专业型硕士：生物与医药，海洋生物工程方向。

三、研究室及联系方式       

实验海洋生物学实验室

联系方式：yueyang@qdio.ac.cn

办公电话：0532-82898703

四、承担的主要科研项目

1.国家自然科学基金青年基金，41906082，2020/01-2022/12，项目负责人；

2.山东省自然科学基金面上项目,ZR2026MS0635,2026.07-2029.06,项目负责人；

3.中科院海洋所自主部署项目，IOCASZZZX107，2025/10-2027/10，项目负责人；

4.中国博士后科学基金面上项目(一等资助)，2018M630805，2018/06-2020/06，项目负责人；

5.山东省自然科学基金，ZR2019BD025，2019/07-2022/06，项目负责人；

6.福建省区域发展项目，2020N3011，2020/08-2022/12，项目技术负责人；                         

五、研究成果及奖励         

海洋科学技术奖一等奖（2018年，排名4/7）                           

六、代表性论文及著作

1. Yuhong Ouyang, Hao Chen, Jing Wang, Ning Wu, Lihua Geng, Quanbin Zhang, Yang Yue*. Discovery of Novel FXIa Inhibitory Peptides from Deep-Sea Gigantidas platifrons Hydrolysates: AI-Guided Screening, Anticoagulant Activity, and Mechanistic Insights[J]. J Agric Food Chem, 2026, 74(25): 19936-19949. (Cover article)

2. Haorui Zhang, Yuhong Ouyang, Suo, Qishan, Hao Chen, Jie Cui, Yang Yue*. From Multi-Species Screening to Targeted Investigation: Discovery of ACE Inhibitory Peptides in Gigantidas platifrons via Peptidomics, Virtual Screening, and Molecular Dynamics Simulations[J]. Molecules, 2026, 31(5): 757.

3. Qishan Suo, Yang Yue*, Jing Wang, Ning Wu, Lihua Geng, Quanbin Zhang*. Discovery and molecular mechanism of a novel antihypertensive peptide from Chlamydomonas reinhardtii based on molecular docking, molecular dynamics simulation, in vitro, and in vivo analysis[J]. Food Research International, 2026, 229: 118477.

4. Qishan Suo, Jing Wang, Ning Wu, Lihua Geng, Quanbin Zhang, and Yang Yue*. 2024. 'Discovery of a novel nanomolar angiotensin-I converting enzyme inhibitory peptide with unusual binding mechanisms derived from Chlorella pyrenoidosa', International Journal of Biological Macromolecules, 280: 135873.

5. Yuhong Ouyang,Yang Yue*, Ning Wu, Jing Wang, Lihua Geng, and Quanbin Zhang*. 2024. 'Identification and anticoagulant mechanisms of novel factor XIa inhibitory peptides by virtual screening of a in silico generated deep-sea peptide database', Food Research International, 197: 115308.

6. Yang Yue, Huahua Yu*, Qishan Suo, Rongfeng Li, Song Liu, Ronge Xing, Quanbin Zhang, Pengcheng Li. Discovery of a novel jellyfish venom metalloproteinase inhibitor from secondary metabolites isolated from jellyfish-derived fungus Aspergillus versicolor SmT07[J]. Chemico-Biological Interactions, 2022, 365: 110113. 

7. Qishan Suo, Yang Yue*, Jing Wang, Ning Wu, Lihua Geng, Quanbin Zhang*. Isolation, identification and in vivo antihypertensive effect of novel angiotensin I-converting enzyme (ACE) inhibitory peptides from Spirulina protein hydrolysate[J]. Food & Function, 2022, 13(17): 9108-9118. 

8. Zhenzhen Deng, Jing Wang, Ning Wu, Lihua Geng, Quanbin Zhang, Yang Yue*. Co-activating the AMPK signaling axis by low molecular weight fucoidan LF2 and fucoxanthin improves the HFD-induced metabolic syndrome in mice[J]. Journal of Functional Foods, 2022, 94: 105119. 

9. Yang Yue, Huahua Yu*, Rongfeng Li, Pengcheng Li*, 2021. Topical exposure to Nemopilema nomurai venom triggers oedematogenic effects: enzymatic contribution and identification of venom metalloproteinase. Toxins,13(1). 

10. Yang Yue, Quanbin Zhang*, Jing Wang, 2019. Integrated gas chromatograph-mass spectrometry (GC/MS) and MS/MS-based molecular networking reveals the analgesic and anti-inflammatory phenotypes of the sea slater Ligia exotica. Marine Drugs,17(7): 395. 

11. Yang Yue, Huahua Yu*, Rongfeng Li, Ronge Xing, Song Liu, Pengcheng Li*, 2019. Insights into individual variations in nematocyst venoms from the giant jellyfish Nemopilema nomurai in the Yellow Sea. Scientific Reports, 9(1): 3361. 

12. Yang Yue, Huahua Yu*, Rongfeng Li, Ronge Xing, Song Liu, Kecheng Li, Xueqin Wang, Xiaolin Chen, Pengcheng Li*, 2017. Functional elucidation of Nemopilema nomurai and Cyanea nozakii nematocyst venoms’ lytic activity using mass spectrometry and zymography. Toxins, 9, 47; doi:10.3390/toxins9020047. 

13. Yang Yue, Huahua Yu* , Rongfeng Li, Ronge Xing, Song Liu, Kecheng Li, Xueqin Wang, Xiaolin Chen, Pengcheng Li*, 2017. Biochemical and kinetic evaluation of the enzymatic toxins from two stinging scyphozoans Nemopilema nomurai and Cyanea nozakii. Toxicon, 125, 1-12.