一、研究领域
1)深海冷泉等特殊生境海洋微生物活性物质的发掘及利用;
2)基于原位富集培养等新手段的新颖深海微生物分离培养;
3)海洋真菌次级代谢产物的代谢调控。
二、招生专业及方向
学术型硕士:海洋生物学,海洋生物天然产物及生物制品/海洋药物与制品方向
专业型硕士:生物与医药
三、研究室及联系方式
E-mail:lixin@qdio.ac.cn
电话: 0532-82898890
通讯地址:山东省青岛市黄岛区海军路88号,中国科学院海洋研究所,
中国科学院实验海洋生物学重点实验室,邮编 266000
四、承担的主要科研项目
1.国家自然科学基金面上项目,深海冷泉难培养真菌的原位富集培养及其代谢产物挖掘和抗肿瘤活性研究,2025/01-2028/12,主持
2.中国科学院青年创新促进会项目,2023/01-2026/12,主持
3.国家重点研发计划青年科学家项目,基于原位富集培养和PSMPA策略的深海冷泉微生物药物先导化合物挖掘技术,2022/11-2025/10,主持
4.国家自然科学基金面上项目,深海冷泉富硫环境中冷泉真菌含硫代谢产物的靶向分离及其抗肝癌活性研究,2021/01-2024/12,主持
5.国家自然科学基金青年项目,基于种间相互作用增加海藻内生真菌次级代谢化学多样性及其抗海洋弧菌活性研究,2018/01-2020/12,主持
6.国家重点研发计划(子课题),深海冷泉微生物代谢产物资源挖掘与药用潜力评估,2018/08-2021/12,主持
7.中国博士后科学基金第61批面上项目,利用诱变策略增加深海真菌次级代谢产物化学多样性研究,2017/05-2019/05,主持
8.山东省自然科学基金,基于有机小分子诱导策略的海洋共生真菌次级代谢产物化学多样性及其生物活性研究,2017/08-2019/12,主持
9.青岛市源头创新计划人才发展专项(青年专项),深海冷泉微生物代谢产物资源挖掘与药用潜力评价,2019/07-2021/07,主持
10.中国科学院科技服务网络计划(STS计划),海岸带生态农牧场关键技术集成与示范(子课题),2018/01-2019/06,主持
五、研究成果及奖励
1、中国科学院青年创新促进会会员
2、研究生国家奖学金
六、近五年代表性论文
1.Li-Hong Yan, Pei-Hai Li, Xiao-Ming Li, Sui-Qun Yang, Ke-Chun Liu, Yun Zhang, Bin-Gui Wang*, Xin Li*. Bialorastins A–F, highly oxygenated and polycyclic andrastin-type meroterpenoids with proangiogenic activity from the deep-sea cold-seep-derived fungus Penicillium bialowiezense CS-283. Bioorganic Chemistry 2024, 143, 107073.
2.Xiao-Dong Li, Xiao-Ming Li, Bin-Gui Wang*, Xin Li*. Antimicrobial sesterterpenoids with a unique 5/8/6/5 tetracyclic carbon-ring-system and diepoxide polyketides from a deep sea-sedimentsourced fungus Chaetomium globosum SD-347. Organic & Biomolecular Chemistry 2024, 22, 3979–3985.
3.Zhenger Wu, Xiao-Ming Li, Sui-Qun Yang, Bin-Gui Wang*, Xin Li*. Antibacterial Polyketides from the Deep-Sea Cold-Seep-Derived Fungus Talaromyces sp. CS-258. Marine Drugs 2024, 22, 204.
4.Chi-Sheng Zhu, Xiao-Ming Li, Sui-Qun Yang, Yi-Wei Liu, Bin-Gui Wang*, Xin Li*. New Hydroxyphenylacetic Acids and α-Pyrone Derivative from the Deep-Sea Cold Seep Sediment-Derived Fungus Penicillium corylophilum CS-682. Chemistry & Biodiversity 2024, e202400584.
5.Lu-Ping Chi#, Dong Liu#, Xiao-Ming Li, Yupeng Wan, Bin-Gui Wang*, Xin Li*. Aspertides A−E: antimicrobial pentadepsipeptides with a unique p‑methoxycinnamoyl amide group from the marine isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512. Journal of Agricultural and Food Chemistry 2023, 71, 13316−13324.
6.Xiao-Dan Chen#, Sui-Qun Yang#, Xiao-Ming Li, Bin-Gui Wang*, Xin Li*. Antibacterial polyketides and ascochlorins from deep-sea cold-seep-derived fungus Furcasterigmium furcatum (syn. Acremonium furcatum). Deep–Sea Research Part I 2023, 199, 104114.
7.Li-Hong Yan, Feng-Yu Du, Xiao-Ming Li, Sui-Qun Yang, Bin-Gui Wang*, Xin Li*. Antibacterial indole diketopiperazine alkaloids from the deep-sea cold seep-derived fungus Aspergillus chevalieri. Marine Drugs 2023, 21, 195.
8.Jun Zhang#, Xin Li#, Rongchang Chen#, Xianwei Tan, Xiongduo Liu, Yaqing Ma, Fangfang Zhu, Chunyan An, Guangzheng Wei, Yongpeng Yao, Lujia Yang, Peng Zhang, Qiaqing Wu, Zhoutong Sun, Bin-Gui Wang*, Shu-Shan Gao*, Chengsen Cui*. Actinomycetes-derived imine reductases with a preference towards bulky amine substrates. Communications Chemistry 2022, 5, 123.
9.Li-Hong Yan, Pei-Hai Li, Xiao-Ming Li, Sui-Qun Yang, Ke-Chun Liu, Bin-Gui Wang*, Xin Li*. Chevalinulins A and B, Proangiogenic Alkaloids with a Spiro[bicyclo[2.2.2]octane-diketopiperazine] Skeleton from Deep-Sea Cold-Seep-Derived Fungus Aspergillus chevalieri CS-122. Organic Letters 2022, 24, 2684−2688.
10.Li-Hong Yan, Xiao-Ming Li, Lu-Ping Chi, Xin Li*, Bin-Gui Wang*. Six New Antimicrobial Metabolites from the Deep-Sea Sediment-Derived Fungus Aspergillus fumigatus SD-406. Marine Drugs 2022, 20, 4.
11.Xin Li#, Li Li#, Xiao-Ming Li, Hong-Lei Li, Belma Konuklugil, Bin-Gui Wang*. Ustusaustin A: A New Neuraminidase Inhibitory Meroterpene from the Ascidian-Derived Endophytic Fungus Aspergillus ustus TK-5. Natural Product Research 2021, 35, 4939–4944.
12.Lu-Ping Chi, Xiao-Ming Li, Yu-Peng Wan, Xin Li*, Bin-Gui Wang*. Ophiobolin Sesterterpenoids and Farnesylated Phthalide Derivatives from the Deep Sea Cold-Seep-Derived Fungus Aspergillus insuetus SD-512. Journal of Natural Products 2020, 83, 3652−3660.
13.Lu-Ping Chi, Xiao-Ming Li, Li Li, Xin Li*, Bin-Gui Wang*. Cytotoxic Thiodiketopiperazine Derivatives from the Deep Sea-Derived Fungus Epicoccum nigrum SD-388. Marine Drugs 2020, 18, 160.
14.Xin Li, Xiao-Ming Li, Bin-Gui Wang*. Structural Revision of Wentiquinone C and Related Congeners from Anthraquinones to Xanthones Using Chemical Derivatization and NMR Analysis. Marine Drugs, 2019, 17, 8.