海洋生物学
 郇聘,博士,研究员,中科院实验海洋生物学重点实验室副主任,从事海洋软体动物发育生物学与遗传改良研究。在软体动物体轴形成、贝壳发育、幼虫变态等重要发育事件的机制研究方面取得重要进展,建立了适用于海洋软体动物的基因编辑技术。在PNASMolecular Biology and Evolution, Nature Ecology & Evolution等期刊发表论文40余篇,代表性研究论文受到F1000Prime推荐,另有授权发明专利7项,参与撰写专著1部。先后主持国家自然科学基金项目3项,参与国家重点研发计划、农业部产业体系岗位科学家项目、海洋试点国家实验室研究课题等多项国家及省部级研究项目。先后入选中国科学院青年创新促进会会员和中国科学院海洋研究所汇泉青年学者,获张福绥贝类学奖“青年创新奖”。



一、研究领域

1.海洋生物发育机制及演化意义

2.典型性状的遗传基础及

3.软体动物基因编辑技术及应用

二、招生专业及方向

1. 博士及学术型硕士:

海洋生物学,繁殖、发育与调控技术方向

海洋生物学,遗传学与遗传工程方向

水产养殖,养殖遗传学与育种生物技术方向

2. 专业型硕士:

生物与医药,海洋生物工程方向

三、研究室及联系方式      

研究室:实验海洋生物学重点实验室

邮箱:huanpin@qdio.ac.cn

电话:0532-82898863  

四、承担的主要科研项目

1、国家自然科学基金面上项目,皱纹盘鲍酪氨酸酶基因家族对贝壳性状的调控机制研究(32273128),2023/01-2026/1254万元,主持,在研。

2、青岛海洋科学与技术试点国家实验室“十四五”重大项目课题,特征器官的发育调控与谱系溯源(2022QNLM050101-2),2022/5-2025/4400万元,主持,在研。

3、国家重点研发计划项目课题,贝类生长与品质性状的分子基础和调控机理研究(2018YFD0900104),2018/12-2022/12746万元,子课题负责人,在研。

4、山东省人才项目,2021/1-2025/1250万元,主持,在研。

5、国家自然科学基金面上项目,小G蛋白cdc42及下游效应基因维持贝壳发育区细胞边界的机制研究(41776157),2018/01-2021/1268万元,主持,已结题。

6、国家自然科学基金青年项目,酪氨酸酶及相关调控基因在长牡蛎幼虫期胚壳发生中的功能研究(31001102),2011/01-2013/1219万元,主持,已结题。

7、中国科学院青年创新促进会人才项目,2018/01-2021/1280万元,主持,已结题。

8、中国科学院海洋研究所“汇泉青年学者”人才项目,2018/01-2020/1250万元,主持,已结题。

五、代表性论文及著作

1.Huan, P.#, Wang, Q.#, Tan, S., & Liu, B. (2020). Dorsoventral decoupling of Hox gene expression underpins the diversification of molluscs. PNAS, 117(1), 503–512. (F1000Prime Recommended)

2.Tan, S.#, Huan, P.#, & Liu, B. (2022). Molluskan Dorsal–Ventral Patterning Relying on BMP2/4 and Chordin Provides Insights into Spiralian Development and Evolution. Molecular Biology and Evolution, 39(1), 1–18.

3.Wang, S.#, Zhang, J.#, Jiao, W.#, Li, J.#, Xun, X.#, Sun, Y.# Guo, X.#, Huan, P.# et al. (2017). Scallop genome provides insights into evolution of bilaterian karyotype and development. Nature Ecology & Evolution, 1(5), 0120. (封面论文)

4.Liu, X.#, Huan, P.#, & Liu, B. (2022). Nonmuscle Myosin II is Required for Larval Shell Formation in a Patellogastropod. Frontiers in Cell and Developmental Biology, 10(February), 1–11.

5.Sun, D., Huan, P., & Liu, B. (2022). Early mesodermal development in the patellogastropod Lottia goshimai. Evolutionary Applications, November 2021, 1–12.

6.Huan, P., Cui, M., Wang, Q., & Liu, B. (2021). CRISPR/Cas9-mediated mutagenesis reveals the roles of calaxin in gastropod larval cilia. Gene, 787, 145640.

7.Yang, W., Huan, P.*, & Liu, B. (2020). Early shell field morphogenesis of a patellogastropod mollusk predominantly relies on cell movement and F-actin dynamics. BMC Developmental Biology, 20(1), 18.

8.Liu, G., Huan, P., & Liu, B. (2020). Identification of three cell populations from the shell gland of a bivalve mollusc. Development Genes and Evolution, 230(1), 39–45.

9.Tan, S., Huan, P.*, & Liu, B. (2018). An investigation of oyster TGF-β receptor genes and their potential roles in early molluscan development. Gene, 663, 65–71.

10.Liu, G., Huan, P.*, & Liu, B. (2017). A SoxC gene related to larval shell development and co-expression analysis of different shell formation genes in early larvae of oyster. Development Genes and Evolution, 227(3), 181–188.

11.Tan, S., Huan, P., & Liu, B. (2017). Expression patterns indicate that BMP2/4 and Chordin, not BMP5-8 and Gremlin, mediate dorsal–ventral patterning in the mollusk Crassostrea gigas. Development Genes and Evolution, 227(2), 75–84.

12.Huan, P., Wang, H., & Liu, B. (2016). Assessment of housekeeping genes as internal references in quantitative expression analysis during early development of oyster. Genes & Genetic Systems, 91(5), 257–265.

13.Huan, P., Wang, H., & Liu, B. (2015). A label-free proteomic analysis on competent larvae and juveniles of the Pacific oyster Crassostrea gigas. PLoS One, 10(8), e0135008.

14.Wang, X., Liu, B., Liu, F., & Huan, P.* (2015). A calaxin gene in the Pacific oyster Crassostrea gigas and its potential roles in cilia. Zoological Science, 32(5), 419–426.

15.Liu, G., Huan, P., & Liu, B. (2015). A GATA2/3 gene potentially involved in larval shell formation of the Pacific oyster Crassostrea gigas. Development Genes and Evolution, 225(4), 253–257.

16.Huan, P., Liu, G., Wang, H., & Liu, B. (2014). Multiple ferritin subunit genes of the Pacific oyster Crassostrea gigas and their distinct expression patterns during early development. Gene, 546(1), 80–88.

17.Huan, P., Liu, G., Wang, H., & Liu, B. (2013). Identification of a tyrosinase gene potentially involved in early larval shell biogenesis of the Pacific oyster Crassostrea gigas. Development Genes and Evolution, 223(6), 389–394.

18.Huan, P., Wang, H., Dong, B., & Liu, B. (2012). Identification of differentially expressed proteins involved in the early larval development of the Pacific oyster Crassostrea gigas. Journal of Proteomics, 75(13), 3855–3865.

19.Huan, P., Wang, H., & Liu, B. (2012). Transcriptomic Analysis of the Clam Meretrix meretrix on Different Larval Stages. Marine Biotechnology, 14(1), 69–78.

20.Huan, P., Zhang, X., Li, F., Zhao, C., Zhang, C., & Xiang, J. (2010). Chromosomal localization of 5S rDNA in Chinese shrimp (Fenneropenaeus chinensis): A chromosome-specific marker for chromosome identification. Chinese Journal of Oceanology and Limnology, 28(2), 233–238.