海洋生物学

孙超岷,中国科学院海洋研究所研究员、博士生导师。2006年于中科院微生物研究所获得博士学位;2007-2013年在美国加州大学伯克利分校进行博士后工作。2014年入选中科院百人计划”, 2015年获得青岛海洋科学与技术国家实验室鳌山人才优秀青年学者称号, 2016年获得山东省自然科学杰出青年基金及泰山学者青年专家称号,2018年获得青岛市创新创业领军人才称号;2022年获得曾成奎(青年)海洋科技奖。在PNASISME JmBioJournal of Hazardous MaterialsmSystemsJournal of Biological ChemistryEnvironmental MicrobiologyApplied Environmental MicrobiologyMolecular MicrobiologyJournal of Bacteriology等生物学领域杂志发表学术论文60余篇。

一、研究领域 

1)深海微生物菌种及基因资源发掘。

    针对深海特殊重要难培养微生物类群,建立基于共培养、模拟培养、原位富集的培养技术,以及基于流式细胞术、微流控等的单细胞高通量分离技术,获得难培养微生物菌种资源;通过单细胞基因组扩增测序、元基因组深度测序及文库构建等手段获得未培养微生物的基因资源,建立高容量的深海微生物菌种及基因资源库。

2)深海微生物特殊生命过程认知。

    基于深海冷泉、热液、深渊等极端环境下的微生物,围绕深海微生物特殊能量代谢机制及耐受深海极端环境的生命特征,发现特殊生命现象,揭示相应生命过程和机制,为发掘新型活性物质的发掘提供物质和理论基础。

3)深海微生物活性物质的发掘和利用。

建立深海微生物活性物质库,构建高通量筛选模型(抗病、抗肿瘤、降解塑料等活性),发掘有应用潜力的活性物质,揭示活性物质的生物合成及作用机制,发展人体医药、生物农药及环境保护相关生物制品。

                   

二、招生专业及方向

海洋生物天然产物及生物制品

三、研究室及联系方式      

中国科学院海洋研究所实验海洋生物学重点实验室

电话:0532-82898857    E-mail: sunchaomin@qdio.ac.cn

四、承担的主要科研项目

1) 中国科学院百人计划资助项目,2015.1- 2019.3

2)青岛海洋与技术国家实验室鳌山人才优秀青年学者项目,2016.1-2020.12

3)山东省自然科学基金杰出青年项目,2016.9-2019.12

4)山东省泰山学者青年专家项目,2017.1-2021.12

5)青岛市创新创业领军人才项目,2018.1-2020.12

6)科技部重点研发计划(深海冷泉生物多样性、环境适应性与应用潜力评估),2018.9-2021.12

7)大洋协会“深海资源计划”项目(新型深海微生物酶/胞外多糖的应用潜力评价与应用示范),2018.7-2020.12

8)中国科学院先导A专项(深海化能、光合及电活性微生物能量转换过程),2019.1-2023.12

9)国家自然科学基金委重大研究计划培育项目,深海冷泉奇古菌和浮霉菌在生长和驱动氮元素循环过程中的互作机制研究,2021.1-2023.12

10)中国科学院海洋大科学研究中心重点部署项目,深海冷泉厌氧甲烷氧化古菌的分离培养及环境适应机制解析, 2020.12-2023.11

11)青岛海洋科学与技术试点国家实验室“十四五”重大项目,微生物介导的地化循环过程及关键生物类群生态功能,2022.5-2025.4                 

五、研究成果及奖励       

1)科研成果:围绕“深海微生物资源发掘利用”,着力突破深海微生物高效获取的关键技术瓶颈,创新性建立了特定物质代谢驱动的微生物纯培养技术,获得了一批深海微生物新物种,包括多个难培养微生物类群;从元素循环驱动、光能利用等方面揭示了深海微生物物质代谢和能量转化新机制;发掘了多个在生物医药(抗肿瘤)和环境保护(塑料降解)等领域有良好应用潜力的活性物质,有力提升了深海微生物在重大疾病防治和新兴污染物去除领域的应用潜能。在PNASISME JmBiomSystemsJournal of Biological ChemistryEnvironmental MicrobiologyApplied and Environmental Microbiology等本领域权威期刊发表论文60 余篇。

2)承担项目:主持了包括国家自然科学基金面上项目、中科院先导专项、大洋协会深海生物资源计划、山东省杰青等在内的十余项科研项目。

3)团队建设:获得了中科院百人计划、山东省杰青、山东省泰山学者青年专家在内的人才称号。组建了包括研究员、副研究员、助理研究员、博士后、及研究生在内共18人的科研团队。培养的研究生中,共有13人次荣获“中科院院长优秀奖、”“国家奖学金”、中科院“地奥”奖学金、中科院“刘瑞玉海洋科学奖”等奖学金及山东省优秀硕士论文。

六、代表性论文及著作

(1)Ruining Cai, Wanying He, Rui Liu, Jing Zhang, Xin Zhang, Chaomin Sun*. Deep-sea in situ insights into the formation of zero-valent sulfur driven by a bacterial thiosulfate oxidation pathway. mBio, 2022, 13(4). Doi: 10.1128/mbio.00143-22.

(2)Rongrong Gao, Rui Liu, Chaomin Sun*. A marine fungus Alternaria alternata FB1 efficiently degrades polyethylene. Journal of Hazardous Materials, 2022, 431: 128617. Doi: 10.1016/j.jhazmat.2022.128617.

(3)Rikuan Zheng, Ruining Cai, Chong Wang, Rui Liu, Chaomin Sun*. Characterization of the first cultured representative of “Candidatus Thermofonsia” Clade 2 within Chloroflexi reveals its phototrophic lifestyle. mBio, 2022, 13(2): e00287-22. Doi: 10.1128/mbio.00287-22.

(4)Yeqi Shan, Ge Liu, Ruining Cai, Rui Liu, Rikuan Zheng, Chaomin Sun*. A deep-sea bacterium senses blue light via a BLUF-dependent pathway. mSystems, 2022, 7(1): e01279-21. Doi: 10.1128/msystems.01279-21.

(5)Rikuan Zheng, Rui Liu, Yeqi Shan, Ruining Cai, Ge Liu, Chaomin Sun*. Characterization of the first cultured free-living representative of Candidatus Izemoplasma uncovers its unique biology. ISME J, 2021, 15(9):2676-2691. doi: 10.1038/s41396-021-00961-7.

(6)Ge Liu, Rui Liu, Yeqi Shan, Chaomin Sun*. Marine bacterial exopolysaccharide EPS11 inhibits migration and invasion of liver cancer cells by directly targeting collagen I. Journal of Biological Chemistry, 2021, doi: https://doi.org/10.1016/j.jbc.2021.101133.

(7)Rikuan Zheng, Ruining Cai, Rui Liu, Ge LiuChaomin Sun*. Maribellus comscasis sp. nov., a novel deep-sea Bacteroidetes bacterium, possessing a prominent capability of degrading cellulose. Environmental Microbiology, 2021, 23(8):4561-4575. Doi: 10.1111/1462-2920.15650.

(8)Ge Liu, Yeqi Shan, Rikuan Zheng, Rui Liu, Chaomin Sun*. Growth promotion of a deep-sea bacterium by sensing infrared light through a bacteriophytochrome photoreceptor. Environmental Microbiology, 2021, 23(8):4466-4477. Doi: 10.1111/1462-2920.15639.

(9)Rongrong Gao, Chaomin Sun*. A marine bacterial community capable of degrading poly(ethylene terephthalate) and polyethylene. Journal of Hazardous Materials, 2021, 416, 125928. doi: 10.1016/j.jhazmat.2021.125928.

(10)Ning Ma, Ruining Cai, Chaomin Sun*. Threonine dehydratase enhances bacterial cadmium resistance via driving cysteine desulfuration and biomineralization of cadmium sulfide nanocrystals. Journal of Hazardous Materials, 2021, 417:126102. doi: 10.1016/j.jhazmat.2021.126102.

(11)Ruining Cai, Jing Zhang, Rui Liu, Chaomin Sun*. Metagenomic insights into the metabolic and ecological functions of abundant deep-sea hydrothermal vent DPANN archaea. Applied and Environmental Microbiology, 2021, 87(9):e03009-20. doi: 10.1128/AEM.03009-20.

(12)Ning Ma, Chaomin Sun*. Cadmium sulfide nanoparticle biomineralization and biofilm formation mediate cadmium resistance of the deep-sea bacterium Pseudoalteromonas sp. MT33b. Environmental Microbiology Reports, 2021, 13(3):325-336. doi: 10.1111/1758-2229.12933.

(13)Rikuan Zheng, Shimei Wu, Chaomin Sun*. MerF is a novel regulator of deep-sea Pseudomonas stutzeri flagellum biogenesis and motility. Environmental Microbiology, 2021, 23(1):110-125. doi: 10.1111/1462-2920.15275.

(14)Ning Ma, Zhongli Sha, Chaomin Sun*. Formation of cadmium sulfide nanoparticles mediates cadmium resistance and light utilization of the deep-sea bacterium Idiomarina sp. OT37-5b. Environmental Microbiology, 2021, 23(2):934-948. doi: 10.1111/1462-2920.15205.

(15)Zuodong Wu, Rikuan Zheng, Ge Liu, Rui Liu, Shimei Wu*, Chaomin Sun *. Calcium protects bacteria against    cadmium stress via reducing nitric oxide production and increasing iron acquisition. Environmental Microbiology, 2021, 23(7):3541-3553. doi: 10.1111/1462-2920.15237.

(16)Shengnan Zhou, Ge Liu, Rikuan Zheng, Chaomin Sun*, Shimei Wu*. Structural and functional insights of iturin W, a novel lipopeptide produced by the deep-sea bacterium Bacillus sp. wsm-1Applied and Environmental Microbiology, 2020, 86(21):e01597-20 DOI: 10.1128/AEM.01597-20.

(17)Rui Liu, Rikuan Zheng, Ge Liu, Chaomin Sun*. The cyclic lipopeptides suppress the motility of Vibrio alginolyticus via targeting the Na+-driven flagellar motor component MotX. Environmental Microbiology, 2020, 22(10): 4424-4437. DOI: 10.1111/1462-2920.15144.

(18)Jing Zhang, Rui Liu, Shichuan Xi, Ruining Cai, Xin Zhang, Chaomin Sun*. A novel      bacterial thiosulfate oxidation pathway provides a new clue about the formation of zero-valent sulfur in deep sea. ISME J, 2020, 14(9):2261-2274. DOI: 10.1038/s41396-020-0684-5.

(19)Ge Liu, Shan Kuang, Ruobing Cao, Ju Wang, Quancai Peng, Chaomin Sun*. Sorafenib kills Huh7.5 liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via ATP-AMPK-mTOR-SREBP1 signaling pathway. FASEB J. 2019, 33(9), doi: 10.1096/fj.201802619RR.

(20)Ge Liu, Kai Wang, Shan Kuang, Ruobing Cao, Li Bao, Rui Liu, Hongwei Liu*, Chaomin Sun*. The natural compound GL22, isolated from Ganoderma mushrooms, suppresses tumor growth by altering lipid metabolism and triggering cell death. Cell Death and Disease, 2018, 9(689), doi: 10.1038/s41419-018-0731-6.

(21)Linlin Zhang, Chaomin Sun*. Fengycins, cyclic lipopeptides from marine Bacillus subtilisstrains, kill the plant-pathogenic fungus Magnaporthe grisea by inducing reactive oxygen species production and chromatin condensation. Applied and Environmental Microbiology, 2018, 84(18).

(22)Pengyuan Xiu, Rui Liu, Dechao Zhang*, Chaomin Sun*. Pumilacidin-like lipopeptides derived from marine bacterium Bacillus sp. suppress the motility of Vibrio alginolyticus. Applied and Environmental Microbiology, 2017, 83(12). doi: 10.1128/AEM.00450-17.

(23)Chaomin SunJordi Querol-AudiStefanie A. MortimerErnesto Arias-PalomoJennifer A. DoudnaEva NogalesJamie H. D. Cate. Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation. Nucleic Acids Research, 2013, 41(15): 7512-7521,

(24)Chaomin Sun, Todorovic A, Querol-Audí J, Bai Y, Villa N, Snyder M, Ashchyan J, Lewis CS, Hartland A, Gradia S, Fraser C, Doudna J, Nogales E, Cate J. Functional reconstitution of human translation initiation factor eIF3. PNAS, 2011 108(51): 20473-8.

(25)Chaomin Sun#, Meixian Zhou, Yun Li, Hua Xiang. Molecular characterization of the minimal replicon and the unidirectional theta replication of pSCM201 in extremely halophilic archaea. Journal of Bacteriology, 2006, 188(23): 8136-8144.

(26)Chaomin Sun, Yun Li, Shuangshuang Mei, Qiuhe Lu, Ligang ZhouHua Xiang. A single gene directs both production and immunity of halocin C8 in a haloarchaeal strain AS7092. Molecular Microbiology, 2005, 57 (2), 537–549.

具体信息请参见实验室网页:

     http://www.qdio.ac.cn/emblc/group/hywswtssmgcrzjhxwzfjly/yjzjs_51426/