王昊，男，副研究员

教育经历: 

l 1999.09-2003.07，理学学士，海洋生物技术, 中国海洋大学；

l 2003.09-2006.07，硕士研究生，海洋生物学, 中国科学院海研究所；

l 2006.09-2011.01，博士研究生，生物学, 香港科技大学生物系。

工作经历: 

l 2011.01-2011.09，博士后，生物系，香港科技大学；

l 2011.09-2014.09，博士后，分子细胞及发育生物学系, 加州大学圣芭芭拉分校；

l 2015.02- 2016.12，副研究员，实验海洋生物学重点研究室，中国科学院海洋研究所；

l 2017.1 - ，副研究员，深海极端环境与生命过程研究中心，中国科学院海洋研究所。

一、研究领域  

l海洋动物-微生物共生互作机制；

l海洋动物极端环境适应机制；

l幼虫生物学、幼虫生态学及幼虫变态附着分子机制; 

l海洋无脊椎动物分子免疫。

l海洋生产力

l海洋生物多样性与进化

l生理、生化过程与调控

三、研究室及联系方式       

l深海极端环境与生命过程研究中心

l邮箱：haowang@qdi.ac.cn

l电话：0532-82898726  

近年主要科研项目: 

l国家自然科学基金面上项目，平端深海偏顶蛤腹侧末端分生细胞与甲烷氧化菌共生建立及甲烷响应机制的研究，2025.01-2028.12，48万元，主持

l青岛海洋科学与技术试点国家实验室“十四五”重大项目，深海生物多样性的多界面过程的驱动机制和保护策略，2022.1-2024.12, 65万元，主持子课题

l中科院重点部署项目，深海化能生态系统大型生物及其共生微生物营养策略及代谢偶联机制研究，2021.01- 2023.12，100万元，，主持

l科技部重点研发专项，2018YFC0310702，深海热液区生物资源研究，2018.08-2021.12，100 万元，主持子课题

l海洋科学与技术国家实验室鳌山科技创新计划项目，2016ASKJ14，深海专项（预研）深海典型生境生物多样性与生态系统，2016.12-2018.12，789.94 万元，主持子课题

l科学”号高端用户项目，KEXUE2016G06，深海热液区管虫转录组及微生物组的初步研究，2016.01-2016.12，人民币 25 万元，主持

王昊，中国科学院海洋研究所副研究员，长期致力于海洋无脊椎动物的进化发育与海洋动物共生关系的研究。近年来，其研究重点聚焦于深海极端环境（如冷泉、热液）下的化能生态系统。通过深海原位实验，深海原位单细胞等技术手段，系统深入地研究了深海共生动物及其宿主-共生菌的互作网络。研究结果揭示了深海共生动物对化能营养的适应机制，以及宿主与共生菌之间复杂的共生关系及分子调控机制。他在海洋共生领域的研究成果发表于Science Advances，PLOS Biology, eLife，ISME J，Animal Biome，iScience，Deep-sea Research等国际主流期刊，主持和参与了国家自然科学基金面上项目、国家重点研发计划、鳌山科技创新等多个科研项目。

Hao Wang, Lei Cao,Huan Zhang, Zhaoshan Zhong, Li Zhou, Chao Lian, Xiaocheng Wang, Hao Chen, Minxiao Wang, Xin Zhang, Chaolun Li* “A deep-sea hydrothermal vent worm detoxifies arsenic and sulfur by intracellular biomineralization of orpiment  (As₂S₃)”, PLOS Biology, 10.1371/journal.pbio.3003291(2025)

Hao Wang(#), Hongxiu Xiao(#), Buhan Feng, Yi Lan, Cheuk Wang Fung,  Huan Zhang,  Guoyong Yan, Chao Lian, Zhaoshan Zhong,  Jing Li, Minxiao Wang, Angela Ruohao Wu*, Chaolun Li*, Pei-Yuan Qian*. “Single-cell RNA-seq revealed distinct metabolic “micro-niches” and close host-symbiont interactions in deep-sea chemosynthetic tubeworm”, Science Advances 10,eadn3053(2024). 

Hao Wang(#), Kai He(#), Huan Zhang(#), Quanyong Zhang(#), Lei Cao, Jing Li, Zhaoshan Zhong, Hao Chen, Li Zhou, Chao Lian, Minxiao Wang, Kai Chen, Pei-Yuan Qian*, and Chaolun Li*. "Deciphering deep-sea chemosynthetic symbiosis by single-nucleus RNA- sequencing", elife 88294.4 (2024)

Jing Li(#), Hao Wang(#), and Chaolun Li* “Single-Cell Sequencing on Marine Life: Application and Future Development”, Frontiers in Marine Science 9, (2022).

Hao Wang, Huan Zhang, Zhaoshan Zhong, Yan Sun, Minxiao Wang, Hao Chen, Li Zhou, Lei Cao, Chao Lian and Chaolun Li*. “Molecular analyses of the gill symbiosis of the bathymodiolin mussel Gigantidas platifrons”. iScience 24(1): 101894, (2021).

Hao Wang(#), Huan Zhang(#), Minxiao Wang, Hao Chen, Chao Lian, Chaolun Li*, “Comparative transcriptomic analysis illuminates the host-symbiont interactions in the deep-sea mussel Bathymodiolus platifrons”, Deep-Sea Res Pt I 151 (2019).

Hao Wang, Huan Zhang, Minxiao Wang, Hao Chen, Chao Lian, Chaolun Li*, “The complete mitochondrial genome of Paralvinella hessleri: an endemic species of deepsea hydrothermal vent”, Mitochondrial DNA Part B 4(1): 832~833 (2019).

Rui Liu, Qi Cheng, Xiaorui Song, Hao Wang*, Xiudan Wang, Lingling Wang, Beiwei Zhu, Linsheng Song*, “A vital ubiquitin-conjugating enzyme CgUbe2g1 participated in regulation of immune response of Pacific oyster Crassostrea gigas”, Dev Comp Immunol 91:132-142 (2019).

Huan Zhang, Hao Wang*, Hao Chen; Mengqiang Wang; Zhi Zhou; Limei Qiu; Lingling Wang; Linsheng Song*, “The transcriptional response of the Pacific oyster Crassostrea gigas under simultaneous bacterial and heat stress”, Dev Comp Immunol 94: 1-6 (2019).

Yao Xiao, Hao Wang, Yi Lan, Cheng Zhong, Guoyong Yan, Zhimeng Xu, Guanyuan Lu, Jiawei Chen, Tong Wei, Wei Chuen Wong, Yick Hang Kwan, and Pei-Yuan Qian*. “Changes in community structures and functions of the gut microbiomes of deep-sea cold seep mussels during in situ transplantation experiment”, Animal Microbiome 5:17 (2023).

Weiyi She, Hao Wang, Darwin Linardi, Sin Yu Chik, Yi Lan, Feng Chen, Aifang Chen*, and Pei-yuan Qian*. “Mode of action of antifouling compound albofungin in inhibiting barnacle larval settlement”, iScience 26, 106981 (2023).

Yi Lan, Jin Sun, Chong Chen, Hao Wang, Yao Xiao, Maeva Perez, Yi Yang, Yick Hang Kwan, Yanan Sun, Yadong Zhou, Xiqiu Han, Junichi Miyazaki, Tomo-o Watsuji, Dass Bissessur, Jian-Wen Qiu, Ken Takai and Pei-Yuan Qian*. “Endosymbiont population genomics sheds light on transmission mode, partner specificity, and stability of the scaly-foot snail holobiont”, ISME J 16:2132–2143 (2022).

Huan Zhang, Hao Wang*, Rui Liu, Lingling Wang*, Linsheng Song, “Cloning and characterization of a leucine aminopeptidase from Pseudoalteromonas telluritireducens DSM 16098, a strain isolated from hydrothermal vents fluid”, Deep-Sea Res Pt I 138:114121 (2018).

Hao Chen, Hao Wang*, Shuai Jiang, Jiachao Xu, Lingling Wang, Limei Qiu, Linsheng Song*, “An oyster species-specific miRNA scaffold42648_5080 modulates haemocyte migration by targeting integrin pathway”. Fish Shellfish Immunol, 57:160–169 (2016). 

Xiaorui Song, Hao Wang, Hao Chen, Mingzhe Sun, Zhongxiu Liang, Lingling Wang, Linsheng Song*, “Conserved hemopoietic transcription factor Cg-SCL delineates hematopoiesis of Pacific oyster Crassostrea gigas”, Fish Shellfish Immunol, 51:180-188 (2016). 

Zhang-Fan Chen, Hao Wang, Pei-Yuan Qian*, “Characterization and expression of calmodulin gene during larval settlement and metamorphosis of the polychaete Hydroides elegans”, Comparative biochemistry and physiology / B : CBP Comp. Biochem, 162(4):113-119 (2012). 

Jin Sun, Huoming Zhang, Hao Wang, Horacio Heras, Marcos S. Dreon, Santiago Ituarte, Timothy Ravasi, Pei-Yuan Qian, Jian-Wen Qiu*. “First proteome of the egg perivitelline fluid of a freshwater gastropod with aerial oviposition”, Journal of Proteome Research 11: 4240-4248 (2012). 

Jin Sun, Wang, M., Hao Wang, Huoming Zhang; X. Zhang, Vengatesen Thiyagarajan, Pei-Yuan Qian, JianWen Qiu*. “De novo assembly of the transcriptome of an invasive snail and its multiple ecological applications”, Molecular Ecology Resources 12(6):1133-1144 (2012).

Zhang-Fan Chen(#), Kiyotaka Matsumura(#), Hao Wang(#), Shawn M Arellano, Xingcheng Yan, Intikhab Alam, John A C Archer, Vladimir B Bajic, Pei-Yuan Qian*. “Toward an understanding of the molecular mechanisms of barnacle larval settlement: a comparative transcriptomic approach”, PLos One, 6(7):p e22913 (2011). 

Huoming Zhang(#), Yue Him Wong(#), Hao Wang(#), Zhang-fan Chen, Shawn M. Arellano, Timothy Ravasi, PeiYuan Qian*. Quantitative proteomics identify molecular targets that are crucial in larval settlement and metamorphosis of Bugula neritina. Journal of Proteome Research, 10(1):349 (2011). 

Hao Wang, Pei-Yuan Qian*. “Involvement of a Novel p38 Mitogen-activated protein kinase in Larval metamorphosis of the Polychaete Hydorides elegans (Hashwell)”, Journal of Experimental Zoology, Part B (Mol. Dev. Evol.) 312B:1–13 (2010).