孙超岷，中国科学院海洋研究所研究员、博士生导师。近年来致力于海洋微生物资源生命过程认知及应用潜力发掘，突破了多个深海难培养微生物高效获取的关键技术瓶颈，从光能利用、暗氧产生等方面揭示了系列深海微生物物质代谢和能量转化新机制，发掘了多个在生物医药和环境保护等领域有良好应用潜力的活性物质。在Nature Communications、PNAS、EMBO J、ISME J、eLife、mBio等本领域专业期刊发表论文90 余篇，承担了国家基金委重点项目、重大研究计划、科技部重点研发计划及中科院先导专项等课题10余项。

一、研究领域 

（1）深海微生物菌种及基因资源发掘。

    针对深海特殊重要难培养微生物类群，建立基于共培养、模拟培养、原位富集的培养技术，以及基于流式细胞术、微流控等的单细胞高通量分离技术，获得难培养微生物菌种资源；通过单细胞基因组扩增测序、元基因组深度测序及文库构建等手段获得未培养微生物的基因资源，建立高容量的深海微生物菌种及基因资源库。

（2）深海微生物特殊生命过程认知。

    基于深海冷泉、热液、深渊等极端环境下的微生物，围绕深海微生物特殊能量代谢机制及耐受深海极端环境的生命特征，发现特殊生命现象，揭示相应生命过程和机制，为发掘新型活性物质的发掘提供物质和理论基础。

（3）深海微生物活性物质的发掘和利用。

建立深海微生物活性物质库，构建高通量筛选模型（抗病、抗肿瘤、降解塑料等活性），发掘有应用潜力的活性物质，揭示活性物质的生物合成及作用机制，发展人体医药、生物农药及环境保护相关生物制品。

二、招生专业及方向

海洋生物天然产物及生物制品

三、研究室及联系方式      

中国科学院海洋研究所实验海洋生物学重点实验室

电话：0532-82898857    E-mail: sunchaomin@qdio.ac.cn

四、承担的主要科研项目

承担了国家基金委重点项目、基金委重大研究计划、科技部重点研发计划及中科院先导专项等课题10余项。   

五、研究成果及奖励       

（1）科研成果：围绕“深海微生物资源发掘利用”，着力突破深海微生物高效获取的关键技术瓶颈，创新性建立了特定物质代谢驱动的微生物纯培养技术，获得了一批深海微生物新物种，包括多个难培养微生物类群；从元素循环驱动、光能利用、暗氧产生等方面揭示了深海微生物物质代谢和能量转化新机制；发掘了多个在生物医药（抗肿瘤）和环境保护（塑料降解）等领域有良好应用潜力的活性物质，有力提升了深海微生物在重大疾病防治和新兴污染物去除领域的应用潜能。

（2）团队建设：组建了包括研究员、副研究员、助理研究员、博士后、及研究生在内共18人的科研团队。培养的研究生中，共有16人次荣获“中科院院长优秀奖、”“国家奖学金”、中科院“地奥”奖学金、中科院“刘瑞玉海洋科学奖”等奖学金及山东省优秀博士、硕士论文。

六、代表性论文及著作

(1) Chong Wang, Rikuan Zheng, Chaomin Sun*. Deep-sea viral diversity and their role in host metabolism of complex organic matter. Nature Communications, 2025, 20096. DOI: 10.1038/s41467-025-65207-y.

(2) Fengjuan Lang, Fan Fei, Chaomin Sun*, Shimei Wu*. Highly efficient degradation of polybutylene succinate (PBS) and polycaprolactone (PCL) by a recombinant marine fungal cutinase. Applied and Environmental Microbiology, 2025, e0083325. Doi: 10.1128/aem.00833-25.

(3) Ge Liu, Yeqi Shan, Chaomin Sun*. A novel exopolysaccharide, highly prevalent in marine Spongiibacter, triggers pyroptosis to exhibit potent anticancer effects. FASEB Journal, 2025, 39(14):e70758. Doi: 10.1096/fj.202500412R.

(4) Tianhang Zhang, Ruining Cai, Chaomin Sun*. Light and polyphosphate kinase 2 cooperatively regulate the production of zero-valent sulfur in a deep-sea bacterium. mSystems, 2025, e0047325. doi: 10.1128/msystems.00473-25.

(5) Zhenjie Su, Fan Fei, Rui Liu, Chaomin Sun*. A marine fungus Alternaria alternata FB1 degrades polypropylene. Journal of Hazardous Materials, 2025, 139621. Doi: 10.1016/j.jhazmat.2025.139621.

(6) Fan Fei, Zhenjie Su, Rui Liu, Rongrong Gao, Chaomin Sun*. Efficient biodegradation of poly(butylene adipate-co-terephthalate) in mild temperature by cutinases derived from a marine fungus. Journal of Hazardous Materials, 2024, 480:136008. Doi: 10.1016/j.jhazmat.2024.136008.

(7) Chong Wang, Rikuan Zheng, Tianhang Zhang, Chaomin Sun*. Polysaccharides induce deep-sea Lentisphaerae strains to release chronic bacteriophages. eLife, 2024, 13:RP92345. Doi: https://doi.org/10.7554/eLife.92345.

(8) Rikuan Zheng, Chong Wang, Chaomin Sun*. Deep-sea in situ and laboratory multi-omics provide insights into the sulfur assimilation of a deep-sea Chloroflexota bacterium. mBio, 2024, 15(4):e0000424. doi: 10.1128/mbio.00004-24.

(9) Rongmei Li, Zhenjie Su, Chaomin Sun*, Shimei Wu*. Antibacterial insights into alternariol and its derivative alternariol monomethyl ether produced by a marine fungus. Applied and Environmental Microbiology, 2024, 90(4):e0005824. Doi: https://doi.org/10.1128/aem.00058-24.

(10)   Rui Liu, Ruining Cai, Minxiao Wang, Jing Zhang, Huan Zhang, Chaolun Li*, Chaomin Sun*. Metagenomic insights into Heimdallarchaeota clades from the deep-sea cold seep and hydrothermal vent. Environmental Microbiome, 2024, 19(1):43. DOI: 10.1186/s40793-024-00585-2.

(11)   Rikuan Zheng, Chong Wang, Rui Liu, Ruining Cai, Chaomin Sun*. Physiological and metabolic insights into the first cultured anaerobic representative of deep-sea Planctomycetes bacteria. eLife, 2024, 12:RP89874. Doi: https://doi.org/10.7554/eLife.89874.

(12)   Ruining Cai, Wanying He, Jing Zhang, Rui Liu, Ziyu Yin, Xin Zhang, Chaomin Sun*. Blue light promotes zero-valent sulfur production in a deep-sea bacterium. The EMBO Journal, 2023, 42(12):e112514. DOI: 10.15252/embj.2022112514.

(13)   Rikuan Zheng, Chong Wang, Ruining Cai, Yeqi Shan, Chaomin Sun*. Mechanisms of nucleic acid degradation and high hydrostatic pressure tolerance of a novel deep sea wall-less bacterium. mBio, 2023. Doi: 10.1128/mbio. 00958-23.

(14)   Ruining Cai, Wanying He, Rui Liu, Jing Zhang, Xin Zhang, Chaomin Sun*. Deep-sea in situ insights into the formation of zero-valent sulfur driven by a bacterial thiosulfate oxidation pathway. mBio, 2022, 13(4). Doi: 10.1128/mbio.00143-22.

(15)   Rikuan Zheng, Ruining Cai, Chong Wang, Rui Liu, Chaomin Sun*. Characterization of the first cultured representative of “Candidatus Thermofonsia” Clade 2 within Chloroflexi reveals its phototrophic lifestyle. mBio, 2022, 13(2): e00287-22. Doi: 10.1128/mbio.00287-22.

(16)   Rongrong Gao, Rui Liu, Chaomin Sun*. A marine fungus Alternaria alternata FB1 efficiently degrades polyethylene. Journal of Hazardous Materials, 2022, 431: 128617. Doi: 10.1016/j.jhazmat.2022.128617.

(17)   Yeqi Shan, Ge Liu, Ruining Cai, Rui Liu, Rikuan Zheng, Chaomin Sun*. A deep-sea bacterium senses blue light via a BLUF-dependent pathway. mSystems, 2022, 7(1): e01279-21. Doi: 10.1128/msystems.01279-21.

(18)   Rikuan Zheng, Rui Liu, Yeqi Shan, Ruining Cai, Ge Liu, Chaomin Sun*. Characterization of the first cultured free-living representative of Candidatus Izemoplasma uncovers its unique biology. ISME J, 2021, 15(9):2676-2691. doi: 10.1038/s41396-021-00961-7.

(19)   Ge Liu, Rui Liu, Yeqi Shan, Chaomin Sun*. Marine bacterial exopolysaccharide EPS11 inhibits migration and invasion of liver cancer cells by directly targeting collagen I. Journal of Biological Chemistry, 2021, doi: https://doi.org/10.1016/j.jbc.2021.101133.

(20)   Rikuan Zheng, Ruining Cai, Rui Liu, Ge Liu, Chaomin Sun*. Maribellus comscasis sp. nov., a novel deep-sea Bacteroidetes bacterium, possessing a prominent capability of degrading cellulose. Environmental Microbiology, 2021, 23(8):4561-4575. Doi: 10.1111/1462-2920.15650.

(21)   Ge Liu, Yeqi Shan, Rikuan Zheng, Rui Liu, Chaomin Sun*. Growth promotion of a deep-sea bacterium by sensing infrared light through a bacteriophytochrome photoreceptor. Environmental Microbiology, 2021, 23(8):4466-4477. Doi: 10.1111/1462-2920.15639.

(22)   Rongrong Gao, Chaomin Sun*. A marine bacterial community capable of degrading poly(ethylene terephthalate) and polyethylene. Journal of Hazardous Materials, 2021, 416, 125928. doi: 10.1016/j.jhazmat.2021.125928.

(23)   Ruining Cai, Jing Zhang, Rui Liu, Chaomin Sun*. Metagenomic insights into the metabolic and ecological functions of abundant deep-sea hydrothermal vent DPANN archaea. Applied and Environmental Microbiology, 2021, 87(9):e03009-20. doi: 10.1128/AEM.03009-20.

(24)   Rikuan Zheng, Shimei Wu, Chaomin Sun*. MerF is a novel regulator of deep-sea Pseudomonas stutzeri flagellum biogenesis and motility. Environmental Microbiology, 2021, 23(1):110-125. doi: 10.1111/1462-2920.15275.

(25)   Ning Ma, Zhongli Sha, Chaomin Sun*. Formation of cadmium sulfide nanoparticles mediates cadmium resistance and light utilization of the deep-sea bacterium Idiomarina sp. OT37-5b. Environmental Microbiology, 2021, 23(2):934-948. doi: 10.1111/1462-2920.15205.

(26)   Zuodong Wu, Rikuan Zheng, Ge Liu, Rui Liu, Shimei Wu*, Chaomin Sun *. Calcium protects bacteria against    cadmium stress via reducing nitric oxide production and increasing iron acquisition. Environmental Microbiology, 2021, 23(7):3541-3553. doi: 10.1111/1462-2920.15237.

(27)   Shengnan Zhou, Ge Liu, Rikuan Zheng, Chaomin Sun*, Shimei Wu*. Structural and functional insights of iturin W, a novel lipopeptide produced by the deep-sea bacterium Bacillus sp. wsm-1. Applied and Environmental Microbiology, 2020, 86(21):e01597-20 DOI: 10.1128/AEM.01597-20.

(28)   Rui Liu, Rikuan Zheng, Ge Liu, Chaomin Sun*. The cyclic lipopeptides suppress the motility of Vibrio alginolyticus via targeting the Na+-driven flagellar motor component MotX. Environmental Microbiology, 2020, 22(10): 4424-4437. DOI: 10.1111/1462-2920.15144.

(29)    Jing Zhang, Rui Liu, Shichuan Xi, Ruining Cai, Xin Zhang, Chaomin Sun*. A novel      bacterial thiosulfate oxidation pathway provides a new clue about the formation of zero-valent sulfur in deep sea. ISME J, 2020, 14(9):2261-2274. DOI: 10.1038/s41396-020-0684-5.

(30)    Ge Liu, Shan Kuang, Ruobing Cao, Ju Wang, Quancai Peng, Chaomin Sun*. Sorafenib kills Huh7.5 liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via ATP-AMPK-mTOR-SREBP1 signaling pathway. FASEB J. 2019, 33(9), doi: 10.1096/fj.201802619RR.

(31)    Ge Liu, Kai Wang, Shan Kuang, Ruobing Cao, Li Bao, Rui Liu, Hongwei Liu*, Chaomin Sun*. The natural compound GL22, isolated from Ganoderma mushrooms, suppresses tumor growth by altering lipid metabolism and triggering cell death. Cell Death and Disease, 2018, 9(689), doi: 10.1038/s41419-018-0731-6.

(32)    Linlin Zhang, Chaomin Sun*. Fengycins, cyclic lipopeptides from marine Bacillus subtilisstrains, kill the plant-pathogenic fungus Magnaporthe grisea by inducing reactive oxygen species production and chromatin condensation. Applied and Environmental Microbiology, 2018, 84(18).

(33)    Pengyuan Xiu, Rui Liu, Dechao Zhang*, Chaomin Sun*. Pumilacidin-like lipopeptides derived from marine bacterium Bacillus sp. suppress the motility of Vibrio alginolyticus. Applied and Environmental Microbiology, 2017, 83(12). doi: 10.1128/AEM.00450-17.

(34)    Chaomin Sun，Jordi Querol-Audi，Stefanie A. Mortimer，Ernesto Arias-Palomo，Jennifer A. Doudna，Eva Nogales，Jamie H. D. Cate. Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation. Nucleic Acids Research, 2013, 41(15): 7512-7521,

(35)    Chaomin Sun, Todorovic A, Querol-Audí J, Bai Y, Villa N, Snyder M, Ashchyan J, Lewis CS, Hartland A, Gradia S, Fraser C, Doudna J, Nogales E, Cate J. Functional reconstitution of human translation initiation factor eIF3. PNAS, 2011 108(51): 20473-8.

(36)    Chaomin Sun#, Meixian Zhou, Yun Li, Hua Xiang. Molecular characterization of the minimal replicon and the unidirectional theta replication of pSCM201 in extremely halophilic archaea. Journal of Bacteriology, 2006, 188(23): 8136-8144.

(37)    Chaomin Sun, Yun Li, Shuangshuang Mei, Qiuhe Lu, Ligang Zhou，Hua Xiang. A single gene directs both production and immunity of halocin C8 in a haloarchaeal strain AS7092. Molecular Microbiology, 2005, 57 (2), 537–549.

具体信息请参见实验室网页：

     http://www.qdio.ac.cn/emblc/group/hywswtssmgcrzjhxwzfjly/yjzjs_51426/